ICOS and ICOSLG

Number of citations of the paper that reports this interaction (PMID 11023515)
37

Data Source:
HPRD (in vitro)

		ICOS	ICOSLG
Gene Name		inducible T-cell co-stimulator	inducible T-cell co-stimulator ligand
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function		Receptor Binding
	Biological Process	T Cell Tolerance Induction Immune Response Single Organismal Cell-cell Adhesion T Cell Costimulation	Defense Response Hyperosmotic Response Signal Transduction T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation
Pathways			Costimulation by the CD28 family Adaptive Immune System
Drugs
Diseases
GWAS		Alopecia areata ( 20596022) Celiac disease ( 20190752) Obesity-related traits ( 23251661)	Celiac disease ( 20190752) Crohn's disease ( 18587394 21102463) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		2 interactors: ICOSLG WIF1	1 interactors: ICOS
Entrez ID		29851	23308
HPRD ID		09196	05757
Ensembl ID		ENSG00000163600	ENSG00000160223
Uniprot IDs		Q53QY6 Q9Y6W8	A0N0L8 K4DIA0 O75144
PDB IDs
Enriched GO Terms of Interacting Partners?			T Cell Tolerance Induction Tolerance Induction T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Immune System Development
Tagcloud ?		aberrant adaptive attributed b7 beneficial blockade blocking cd28 checkpoints combinatorial contributions ctla evasion exceptionally existing h4 immunity immunotherapies immunotherapy investigating microenvironment monotherapies pd prompting rely responsiveness restore substantial therapeutics	atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable enah eventually identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation
Tagcloud (Difference) ?		aberrant adaptive attributed b7 beneficial blockade blocking cd28 checkpoints combinatorial contributions ctla evasion exceptionally existing h4 immunity immunotherapies immunotherapy investigating microenvironment monotherapies pd prompting rely responsiveness restore substantial therapeutics	atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable enah eventually identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation
Tagcloud (Intersection) ?