ICOS and WIF1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ICOS	WIF1
Gene Name		inducible T-cell co-stimulator	WNT inhibitory factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Extracellular Region
	Molecular Function		Protein Binding
	Biological Process	T Cell Tolerance Induction Immune Response Single Organismal Cell-cell Adhesion T Cell Costimulation	Signal Transduction Multicellular Organismal Development Wnt Signaling Pathway Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Alopecia areata ( 20596022) Celiac disease ( 20190752) Obesity-related traits ( 23251661)	Hippocampal volume ( 22504421)
Protein-Protein Interactions		2 interactors: ICOSLG WIF1	4 interactors: ICOS KRTAP10-3 KRTAP10-8 RPL37
Entrez ID		29851	11197
HPRD ID		09196	05541
Ensembl ID		ENSG00000163600	ENSG00000156076
Uniprot IDs		Q53QY6 Q9Y6W8	Q9Y5W5
PDB IDs			2D3J 2YGN 2YGO 2YGP 2YGQ
Enriched GO Terms of Interacting Partners?			T Cell Tolerance Induction Tolerance Induction
Tagcloud ?		aberrant adaptive attributed b7 beneficial blockade blocking cd28 checkpoints combinatorial contributions ctla evasion exceptionally existing h4 immunity immunotherapies immunotherapy investigating microenvironment monotherapies pd prompting rely responsiveness restore substantial therapeutics	aberrantly aom apcmin azoxymethane blt1 citrobacter coincided colonocytes crypt crypts deazaneplanocin dextran doi dss dznep epigenetically ezh2 f681y h3k27me3 hydroxamic knocked onc outbred paralleled polyps rodentium suberoylanilide swiss zeste
Tagcloud (Difference) ?		aberrant adaptive attributed b7 beneficial blockade blocking cd28 checkpoints combinatorial contributions ctla evasion exceptionally existing h4 immunity immunotherapies immunotherapy investigating microenvironment monotherapies pd prompting rely responsiveness restore substantial therapeutics	aberrantly aom apcmin azoxymethane blt1 citrobacter coincided colonocytes crypt crypts deazaneplanocin dextran doi dss dznep epigenetically ezh2 f681y h3k27me3 hydroxamic knocked onc outbred paralleled polyps rodentium suberoylanilide swiss zeste
Tagcloud (Intersection) ?