ICOS

Description		inducible T cell costimulator
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity
	Biological Process	T Cell Tolerance Induction Immune Response T Cell Costimulation T Follicular Helper Cell Differentiation Cell-cell Adhesion
Pathways		Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)
Novel Interacting Genes		5 novel interacting genes: ABI2 ADAM23 BRCC3 NIF3L1 TNP1
Interacting Genes		4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1
Entrez ID		29851
HPRD ID		09196
Ensembl ID		ENSG00000163600
Uniprot IDs		Q53QY6 Q9Y6W8
PDB IDs		6X4G 7JOO
Enriched GO Terms of Interacting Partners?		T Follicular Helper Cell Differentiation T Cell Differentiation Involved In Immune Response Regulation Of Activated T Cell Proliferation T-helper Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation Sperm DNA Decondensation Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Zonula Adherens Assembly Cytoplasmic Stress Granule CCR4-NOT Complex Binding Negative Regulation Of Germinal Center Formation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway
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