RNF135

Description		ring finger protein 135
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity RIG-I Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Immune System Process Free Ubiquitin Chain Polymerization Protein Ubiquitination Positive Regulation Of Interferon-beta Production RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Protein Homooligomerization Protein K63-linked Ubiquitination Antiviral Innate Immune Response
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: CTBP2 ENOX2 GOLGA2 HSF2BP IFIH1 MAVS RIGI TEPSIN UBE2D2 UBE2N
Entrez ID		84282
HPRD ID		11506
Ensembl ID		ENSG00000181481
Uniprot IDs		B3KV69 Q8IUD6
PDB IDs		7JL1 7JL3 8G7T 8G7U 8G7V
Enriched GO Terms of Interacting Partners?		Antiviral Innate Immune Response Cellular Response To Exogenous DsRNA Cellular Response To DsRNA Positive Regulation Of Interferon-alpha Production Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Detection Of Virus Response To DsRNA MRNA Transcription Regulation Of Type III Interferon Production Regulation Of Interferon-beta Production Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Positive Regulation Of Response To Cytokine Stimulus Defense Response To Virus Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-activating Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Response To Virus Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Activation Of Immune Response DNA-templated Transcription Regulation Of Interleukin-6 Production Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Activation Of Innate Immune Response Pattern Recognition Receptor Activity Intracellular Receptor Signaling Pathway Regulation Of Defense Response To Virus By Host Single-stranded RNA Binding Innate Immune Response Negative Regulation Of Viral Genome Replication Positive Regulation Of Immune Response Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interleukin-8 Production Positive Regulation Of IP-10 Production Coated Vesicle Membrane Defense Response To Symbiont Positive Regulation Of Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Other Organism
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