CREB3L4 and GET3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CREB3L4	GET3
Description		cAMP responsive element binding protein 3 like 4	guided entry of tail-anchored proteins factor 3, ATPase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Nuclear Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Membrane Insertase Activity Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Spermatogenesis Positive Regulation Of Transcription By RNA Polymerase II	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		CREB3 factors activate genes	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			ATP
Diseases
GWAS		Age at first birth ( 27798627) Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: GANAB GET3 LRRC4C SLC19A3 SOX9	38 interacting genes: AGR2 APLN ASPH CACNA1A CREB3L4 EMSY FAM209A FKBP7 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3
Entrez ID		148327	439
HPRD ID		06323	03555
Ensembl ID		ENSG00000143578	ENSG00000198356
Uniprot IDs		Q8TEY5	O43681
PDB IDs			6SO5 8CQZ 8CR1 8CR2
Enriched GO Terms of Interacting Partners?		Neural Crest Cell Fate Specification Male Germ-line Sex Determination Negative Regulation Of Beta-catenin-TCF Complex Assembly Bronchus Cartilage Development Ureter Urothelium Development Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Regulation Of Cell Proliferation Involved In Tissue Homeostasis Ureter Smooth Muscle Cell Differentiation Lung Smooth Muscle Development Intrahepatic Bile Duct Development Glc2Man9GlcNAc2 Oligosaccharide Glucosidase Activity Glucan 1,3-alpha-glucosidase Activity Glucosidase II Complex Pyridoxine Transport GET Complex Metanephric Tubule Formation Stem Cell Fate Specification Renal Vesicle Induction Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Chondrocyte Hypertrophy Cell Proliferation Involved In Heart Morphogenesis Trachea Cartilage Development Response To Heparin Prostate Gland Morphogenesis Cellular Response To Heparin Anterior Head Development Primary Sex Determination Harderian Gland Development Astrocyte Fate Commitment Common Bile Duct Development Growth Plate Cartilage Chondrocyte Growth Alpha-glucosidase Activity Thiamine Transmembrane Transporter Activity Thiamine Transport Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Transmembrane Transport Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Branching Involved In Lung Morphogenesis Endochondral Bone Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Lacrimal Gland Development Vitamin Transmembrane Transporter Activity Thiamine-containing Compound Metabolic Process Ureter Development Otic Vesicle Formation Ureter Morphogenesis Glial Cell Fate Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis	Extracellular Region Endoplasmic Reticulum Lumen Intracellular Protein Transmembrane Transport Body Fluid Secretion Sec61 Translocon Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Extracellular Space Regulation Of Body Fluid Levels Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Mucus Secretion Potassium Ion Export Across Plasma Membrane Protein Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Regulation Of Heart Contraction Amyloid-beta Binding Glutathione Peroxidase Activity Protein Disulfide Isomerase Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein Binding Regulation Of System Process Protein-disulfide Reductase Activity
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