GET3 and SYPL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GET3	SYPL2
Description		guided entry of tail-anchored proteins factor 3, ATPase	synaptophysin like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome	Synaptic Vesicle Membrane Synaptic Vesicle Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Membrane Insertase Activity Metal Ion Binding	Protein Binding
	Biological Process	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane	Intracellular Calcium Ion Homeostasis Heart Development Substantia Nigra Development T-tubule Organization
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		ATP
Diseases
GWAS			Body mass index ( 29273807) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Estimated glomerular filtration rate ( 31015462 31152163) Glomerular filtration rate (creatinine) ( 26831199 28452372) Major depressive disorder ( 20125088)
Interacting Genes		38 interacting genes: AGR2 APLN ASPH CACNA1A CREB3L4 EMSY FAM209A FKBP7 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3	7 interacting genes: ATP13A1 GET3 PLLP SLC38A7 SLC41A1 SNCA YIPF2
Entrez ID		439	284612
HPRD ID		03555	17478
Ensembl ID		ENSG00000198356	ENSG00000143028
Uniprot IDs		O43681	B4DYR7 Q5VXT5
PDB IDs		6SO5 8CQZ 8CR1 8CR2
Enriched GO Terms of Interacting Partners?		Extracellular Region Endoplasmic Reticulum Lumen Intracellular Protein Transmembrane Transport Body Fluid Secretion Sec61 Translocon Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Extracellular Space Regulation Of Body Fluid Levels Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Mucus Secretion Potassium Ion Export Across Plasma Membrane Protein Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Regulation Of Heart Contraction Amyloid-beta Binding Glutathione Peroxidase Activity Protein Disulfide Isomerase Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein Binding Regulation Of System Process Protein-disulfide Reductase Activity	Response To Magnesium Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Monoatomic Ion Transport L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Inorganic Ion Homeostasis Monoatomic Ion Homeostasis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Monoatomic Cation Homeostasis Regulation Of Transcytosis Magnesium:sodium Antiporter Activity GET Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Asparagine Transport L-asparagine Transmembrane Transporter Activity P-type Transmembrane Transporter Activity Metal Ion Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Compact Myelin P-type Ion Transporter Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Cellular Response To Metal Ion Dopamine Uptake Involved In Synaptic Transmission Sodium Ion Transport Intracellular Magnesium Ion Homeostasis Cellular Response To Magnesium Ion Monoatomic Cation Transport Establishment Of Protein Localization To Membrane Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Calcium Ion Homeostasis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Glutamine Transport L-glutamine Transmembrane Transporter Activity Golgi Trans Cisterna Inorganic Cation Transmembrane Transporter Activity
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