GET3 and GPX7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GET3	GPX7
Description		guided entry of tail-anchored proteins factor 3, ATPase	glutathione peroxidase 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Membrane Insertase Activity Metal Ion Binding	Catalase Activity Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity
	Biological Process	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane	Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Oxidant Detoxification
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Detoxification of Reactive Oxygen Species
Drugs		ATP	Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS			Joint mobility (Beighton score) ( 27182965)
Interacting Genes		38 interacting genes: AGR2 APLN ASPH CACNA1A CREB3L4 EMSY FAM209A FKBP7 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3	13 interacting genes: ASPH CEP70 CPEB2 CPNE7 ERO1A GET3 NCALD NTAQ1 SGTA SGTB TCF25 UBQLN2 UBQLN4
Entrez ID		439	2882
HPRD ID		03555	13606
Ensembl ID		ENSG00000198356	ENSG00000116157
Uniprot IDs		O43681	Q96SL4
PDB IDs		6SO5 8CQZ 8CR1 8CR2	2P31
Enriched GO Terms of Interacting Partners?		Extracellular Region Endoplasmic Reticulum Lumen Intracellular Protein Transmembrane Transport Body Fluid Secretion Sec61 Translocon Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Extracellular Space Regulation Of Body Fluid Levels Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Mucus Secretion Potassium Ion Export Across Plasma Membrane Protein Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Regulation Of Heart Contraction Amyloid-beta Binding Glutathione Peroxidase Activity Protein Disulfide Isomerase Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein Binding Regulation Of System Process Protein-disulfide Reductase Activity	TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway Regulation Of Proteolysis Regulation Of ERAD Pathway Protein Insertion Into ER Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization To Membrane Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Response To Endoplasmic Reticulum Stress Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Cytoplasmic Translational Elongation Protein Insertion Into Membrane Peptidyl-aspartic Acid 3-dioxygenase Activity Cellular Response To Calcium Ion Protein Targeting To Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Protein-N-terminal Asparagine Amidohydrolase Activity Nuclear Proteasome Complex Autophagosome GET Complex Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway RQC Complex Negative Regulation Of Autophagosome Maturation Regulation Of Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process Activation Of Store-operated Calcium Channel Activity Cytosolic Proteasome Complex Negative Regulation Of Translational Elongation Positive Regulation Of Store-operated Calcium Channel Activity Regulation Of Sequestering Of Calcium Ion Response To Calcium Ion Regulation Of Protein-containing Complex Disassembly Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein K48-linked Ubiquitination Cellular Response To Hypoxia Thiol Oxidase Activity Negative Regulation Of ERAD Pathway Cellular Response To Decreased Oxygen Levels
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