GET3 and TMEM51

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GET3	TMEM51
Description		guided entry of tail-anchored proteins factor 3, ATPase	transmembrane protein 51
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome	Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Membrane Insertase Activity Metal Ion Binding	Protein Binding
	Biological Process	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		ATP
Diseases
GWAS			Acute ischemic stroke x type 2 diabetes interaction ( 32541925) Cocaine use disorder ( 31490055) Cocaine use disorder x non-traditional parental care interaction ( 31490055)
Interacting Genes		38 interacting genes: AGR2 APLN ASPH CACNA1A CREB3L4 EMSY FAM209A FKBP7 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3	38 interacting genes: AQP6 ARLN BCL2L13 C14orf180 CCDC167 CCL4L2 CLCA4 CREB3 CYB5R3 CYP4F2 EBP GET3 ITCH LMNA MRPL12 NEDD4 NINJ2 PLP2 PTPN5 REEP4 RTP2 SEC61G SFT2D2 SFXN3 SMAGP SMIM1 STRIT1 TMEM107 TMEM14A TMEM14B TMEM242 TMEM254 TMIE TMX2 TSNARE1 UBE2J1 VAMP4 VTI1B
Entrez ID		439	55092
HPRD ID		03555	07651
Ensembl ID		ENSG00000198356	ENSG00000171729
Uniprot IDs		O43681	Q9BSA0 Q9NW97
PDB IDs		6SO5 8CQZ 8CR1 8CR2
Enriched GO Terms of Interacting Partners?		Extracellular Region Endoplasmic Reticulum Lumen Intracellular Protein Transmembrane Transport Body Fluid Secretion Sec61 Translocon Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Extracellular Space Regulation Of Body Fluid Levels Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Mucus Secretion Potassium Ion Export Across Plasma Membrane Protein Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Regulation Of Heart Contraction Amyloid-beta Binding Glutathione Peroxidase Activity Protein Disulfide Isomerase Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein Binding Regulation Of System Process Protein-disulfide Reductase Activity	Membrane Endoplasmic Reticulum Membrane Mitochondrial Membrane Presynaptic Endosome Membrane Endoplasmic Reticulum SNARE Complex
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