SIX5 and EYA3

Number of citations of the paper that reports this interaction (PMID 10490620)
53

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SIX5	EYA3
Gene Name		SIX homeobox 5	EYA transcriptional coactivator and phosphatase 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome
	Molecular Function	Protein Binding Sequence-specific DNA Binding	Chromatin Binding Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Metal Ion Binding
	Biological Process	Lens Development In Camera-type Eye Transcription, DNA-templated Spermatid Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation	Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ATXN1 EYA3 HMGB1	6 interactors: DACH1 SIX1 SIX2 SIX4 SIX5 ZDHHC17
Entrez ID		147912	2140
HPRD ID		09024	09042
Ensembl ID		ENSG00000177045	ENSG00000158161
Uniprot IDs		Q8N196	Q99504
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Cell Clearance Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Histone Dephosphorylation Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Radiation DNA Ligation Involved In DNA Repair Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Cell Clearance Negative Regulation Of Phagocytosis DNA Ligation Dendritic Cell Chemotaxis DNA Repair Chromatin Modification Apoptotic DNA Fragmentation Chromatin Organization Regulation Of DNA-templated Transcription, Initiation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Dendritic Cell Migration Negative Regulation Of Transcription From RNA Polymerase II Promoter Myeloid Dendritic Cell Activation Positive Chemotaxis V(D)J Recombination Cellular Response To DNA Damage Stimulus Apoptotic Nuclear Changes Inflammatory Response To Antigenic Stimulus DNA Topological Change Positive Regulation Of DNA Repair Positive Regulation Of DNA Binding Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process Negative Regulation Of Endocytosis Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Lung Alveolus Development Regulation Of RNA Metabolic Process Neurological System Process Nucleobase-containing Compound Metabolic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Visual Learning	Regulation Of Branching Involved In Ureteric Bud Morphogenesis Myotome Development Positive Regulation Of Ureteric Bud Formation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Regulation Of Synaptic Growth At Neuromuscular Junction Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Olfactory Placode Formation Trigeminal Ganglion Development Regulation Of Satellite Cell Proliferation Metanephros Development Ear Morphogenesis Embryonic Skeletal System Morphogenesis Myoblast Migration Fungiform Papilla Morphogenesis Sensory Organ Development Regulation Of Cell Proliferation Embryonic Skeletal System Development Fungiform Papilla Development Ganglion Development Protein Localization To Nucleus Regulation Of Skeletal Muscle Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Mesenchyme Development Regulation Of Organ Morphogenesis Tongue Morphogenesis Nose Development Pharyngeal System Development Mesenchyme Development Middle Ear Morphogenesis Ear Development Positive Regulation Of Embryonic Development Skeletal System Morphogenesis Positive Regulation Of Kidney Development Tongue Development Kidney Development Muscle Cell Migration Embryonic Organ Morphogenesis Renal System Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cranial Nerve Development Urogenital System Development Thymus Development Regulation Of Synapse Assembly Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Embryonic Organ Development
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