SIX5

Description		SIX homeobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Lens Development In Camera-type Eye Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatid Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Leydig Cell Proliferation Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation
Pathways
Drugs
Diseases		Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143)
Interacting Genes		3 interacting genes: ATXN1 EYA3 HMGB1
Entrez ID		147912
HPRD ID		09024
Ensembl ID		ENSG00000177045
Uniprot IDs		Q8N196
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Repair Double-strand Break Repair Histone H2AXY142 Phosphatase Activity Regulation Of DNA Repair Regulation Of Mismatch Repair C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex Calcium-dependent Protein Kinase Regulator Activity T-helper 1 Cell Activation Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance POZ Domain Binding Positive Regulation Of DNA Metabolic Process Negative Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Myeloid Progenitor Cell Differentiation Negative Regulation Of Transcription Initiation By RNA Polymerase II Supercoiled DNA Binding Positive Regulation Of Dendritic Cell Differentiation Regulation Of Endodeoxyribonuclease Activity Neutrophil Clearance Transcription By RNA Polymerase II DNA Geometric Change Regulation Of Glycogen Catabolic Process Bubble DNA Binding Poly(G) Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Radiation Nucleic Acid Metabolic Process DNA-templated Transcription Regulation Of Apoptotic Cell Clearance Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Cell Development Regulation Of Toll-like Receptor 9 Signaling Pathway DNA Topological Change Endothelial Cell Chemotaxis Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway RAGE Receptor Binding Nuclear Inclusion Body Regulation Of DNA Metabolic Process DNA Repair Regulation Of T Cell Mediated Immune Response To Tumor Cell
Tagcloud ?