VMA12 and IFNGR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VMA12	IFNGR2
Description		vacuolar ATPase assembly factor VMA12	interferon gamma receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Vacuolar Proton-transporting V-type ATPase Complex COPI-coated Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Oxysterol Binding	Cytokine Receptor Activity Type II Interferon Receptor Activity Protein Binding
	Biological Process	Intracellular Iron Ion Homeostasis Lysosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Vacuolar Proton-transporting V-type ATPase Complex Assembly Lysosomal Protein Catabolic Process	Microglial Cell Activation Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Defense Response To Virus Type II Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Glutamate Receptor Signaling Pathway
Pathways			Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS IFNG signaling activates MAPKs
Drugs			Interferon gamma-1b
Diseases			Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS			Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 22936669 23128233 28067908) Diverticular disease ( 30177863) Educational attainment ( 25201988) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 24076602 31604244) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		17 interacting genes: AQP6 BIK CCR2 CD300A EBP ELOVL4 ERLIN1 IFNGR2 JAGN1 KASH5 LMNA REEP4 SLC10A4 STX1A STX4 TIMMDC1 TMEM14B	42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 VMA12 ZDHHC24
Entrez ID		147007	3460
HPRD ID		12679	00956
Ensembl ID		ENSG00000244045	ENSG00000159128
Uniprot IDs		Q8N511	A8K881 E7EUY1 P38484
PDB IDs			5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?		Membrane Regulation Of Regulated Secretory Pathway Regulation Of Exocytosis Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway SNARE Complex Assembly Regulation Of Secretion By Cell Nuclear Envelope Organization Regulation Of Secretion Endoplasmic Reticulum Membrane Positive Regulation Of Synaptic Transmission Nitrate Transmembrane Transporter Activity Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrial Membrane Organelle Localization SNARE Complex Regulation Of Insulin Secretion Insulin Secretion Positive Regulation Of Regulated Secretory Pathway Regulation Of Peptide Hormone Secretion SNAP Receptor Activity Myosin Head/neck Binding Exocytosis Sphingomyelin Phosphodiesterase Activator Activity Cholesterol-5,6-oxide Hydrolase Activity Negative Regulation Of Secretion Negative Regulation Of Secretion By Cell Negative Regulation Of Eosinophil Activation Negative Regulation Of Exocytosis Negative Regulation Of Phagocytosis, Engulfment Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Nuclear Envelope PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Type II Interferon Receptor Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina SNARE Binding Vesicle Docking Regulation Of Vesicle-mediated Transport Positive Regulation Of Eosinophil Degranulation Membrane Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Storage Vacuole C-8 Sterol Isomerase Activity Cholestenol Delta-isomerase Activity	Membrane Regulation Of Tumor Necrosis Factor Production Type II Interferon-mediated Signaling Pathway Type II Interferon Receptor Binding Oxysterol Binding Macrophage Activation Interferon-mediated Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-23 Production Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Bleb Assembly Cellular Response To Hormone Stimulus Regulation Of Interleukin-23 Production Type III Interferon-mediated Signaling Pathway Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Amyloid-beta Clearance Myeloid Leukocyte Activation Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Virus Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of MHC Class II Biosynthetic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Nitric Oxide Metabolic Process Regulation Of Intracellular Transport Endomembrane System Positive Regulation Of Monocyte Chemotactic Protein-1 Production Neuroinflammatory Response Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Defense Response To Virus Astrocyte Activation Cellular Response To Virus Positive Regulation Of Amyloid-beta Formation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Amyloid-beta Clearance Macrophage Activation Involved In Immune Response Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Steroid Biosynthetic Process Protein Binding
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