CSTF3 and MIRLET7A3

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		CSTF3	MIRLET7A3
Description		cleavage stimulation factor subunit 3	microRNA let-7a-3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage Stimulating Factor Complex	RISC Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding
	Biological Process	RNA Processing MRNA Processing RNA 3'-end Processing MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Anger ( 24489884) Non-response to citalopram or escitalopram and depression ( 27622933)
Interacting Genes		15 interacting genes: CEBPA CSTF1 CSTF2 DLGAP1-AS2 MIR128-2 MIR138-2 MIR15B MIR19A MIR19B1 MIR21 MIR92A2 MIRLET7A3 MIRLET7F2 MIRLET7G MIRLET7I	100 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CELF1 CPSF1 CPSF2 CSTF1 CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PLOD1 PRMT1 PTBP1 PUM1 PUM2 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM12B RBM14 RBM4 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM25 TRMT10C U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346
Entrez ID		1479	406883
HPRD ID		02651
Ensembl ID		ENSG00000176102	ENSG00000283990
Uniprot IDs		Q12996
PDB IDs		6B3X 6URO 7ZY4
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Inflammatory Response Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Defense Response MRNA 3'-UTR Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cell Migration Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Locomotion Negative Regulation Of Inflammatory Response Negative Regulation Of Translation Negative Regulation Of Cell Differentiation Regulation Of Extracellular Matrix Organization Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Endothelial Cell Migration Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Bacterial Lipopeptide Regulation Of Cardiac Muscle Hypertrophy HMG Box Domain Binding Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration Positive Regulation Of Muscle Cell Differentiation Regulation Of Defense Response	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of RNA Splicing Nucleoplasm Nucleus Regulation Of MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Translation MiRNA Binding Ribonucleoprotein Complex Spliceosomal Complex Catalytic Step 2 Spliceosome Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of Translation Regulation Of MRNA Stability Regulation Of Gene Expression Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Stabilization MRNA Stabilization Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression RNA 3'-end Processing TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Metabolic Process TRNA Aminoacylation Ligase Activity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Nucleolus
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