KLC3 and CCNH

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KLC3	CCNH
Gene Name		kinesin light chain 3	cyclin H
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Kinesin Complex Microtubule Motile Cilium Ciliary Rootlet Neuron Projection	Nucleus Nucleoplasm Holo TFIIH Complex Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex TFIIK Complex
	Molecular Function	Microtubule Motor Activity Microtubule Binding Kinesin Binding	Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Axon Cargo Transport Metabolic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways		MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Tat-mediated elongation of the HIV-1 transcript Cyclin E associated events during G1/S transition Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression G1/S Transition Mitotic G1-G1/S phases S Phase Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Transcription of the HIV genome Nucleotide Excision Repair RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation HIV Infection RNA Polymerase I Promoter Clearance Formation of the Early Elongation Complex G2/M Transition RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cyclin A/B1 associated events during G2/M transition RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER RNA Polymerase I Transcription mRNA Capping RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination G1 Phase Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic Cyclin D associated events in G1 Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Major depressive disorder ( 23377640)
Protein-Protein Interactions		35 interactors: ABI3 BBS5 CCDC36 CCDC64B CCNH CENPP CEP57L1 CROCC DTX2 GEM IMP3 KDM1A KIF5A KIF5B KIF5C KRT13 KRT15 MBIP NDC80 NECAB2 PDE4DIP QARS SNAP47 SPERT STX11 TCF4 TSNAX USHBP1 VPS52 WAC YWHAG YWHAH YWHAQ ZNF417 ZNF572	39 interactors: AR CALCOCO2 CCDC170 CCDC33 CCNC CDK2 CDK20 CDK7 CDK8 CSNK2B CTBP2 CTD DUSP12 ERCC3 ESR1 FUBP1 GANAB GOLGA2 GTF2E2 GTF2H1 KLC3 MBP MCM7 MNAT1 MTA1 MYC NDC80 NEDD4 POLR2A POLR2B PPFIA1 PSMA1 RARB SFN SSSCA1 SSX2IP SUPT5H TP53 TRIM8
Entrez ID		147700	902
HPRD ID		03212	09059
Ensembl ID		ENSG00000104892	ENSG00000134480
Uniprot IDs		Q6P597	P51946
PDB IDs			1JKW 1KXU
Enriched GO Terms of Interacting Partners?		Protein Localization Organelle Organization Cellular Localization Organelle Localization Establishment Of Localization In Cell Establishment Of Organelle Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Vesicle Localization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Synaptic Vesicle Fusion To Presynaptic Membrane Establishment Of Vesicle Localization Cellular Protein Localization Cell Cycle Chromosome Organization Positive Regulation Of Intracellular Transport Regulation Of Mitochondrion Organization Protein Transport Microtubule-based Process Establishment Of Protein Localization Intracellular Transport Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Synaptic Transmission Negative Regulation Of Protein Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Hormone Metabolic Process Developmental Process Anatomical Structure Development Substantia Nigra Development Regulation Of Synaptic Plasticity Nervous System Development Regulation Of Establishment Of Protein Localization Embryonic Digestive Tract Development Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Glutaminyl-tRNA Aminoacylation Regulation Of Primitive Erythrocyte Differentiation Histone H2B Conserved C-terminal Lysine Ubiquitination Glucocorticoid Catabolic Process Microtubule Anchoring Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Transport Vesicle Fusion Mitotic Cell Cycle Neural Nucleus Development Synaptic Vesicle Exocytosis Pituitary Gland Development	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine RNA Capping Regulation Of Viral Transcription DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Viral Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Regulation Of Viral Process Nucleotide-excision Repair Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cell Cycle Gene Expression Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Transcription Initiation From RNA Polymerase I Promoter Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase I Promoter DNA Repair Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Heterocycle Metabolic Process Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?			carrying chemotherapy conversely ercc5 ercc6 genotype genotypes genotyping good homozygous hrs longer median mms19l months os osteosarcoma pfs polymorphisms poor rflp rs1047768 rs17655 rs29001322 shorter tt undergoing xpc
Tagcloud (Difference) ?			carrying chemotherapy conversely ercc5 ercc6 genotype genotypes genotyping good homozygous hrs longer median mms19l months os osteosarcoma pfs polymorphisms poor rflp rs1047768 rs17655 rs29001322 shorter tt undergoing xpc
Tagcloud (Intersection) ?