EME1 and MUS81

Number of citations of the paper that reports this interaction (PMID 12721304)
72

Data Source:
HPRD (in vitro)

		EME1	MUS81
Gene Name		essential meiotic structure-specific endonuclease 1	MUS81 structure-specific endonuclease subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Heterochromatin Nucleolus Cytoplasm	Nucleus Nucleolus
	Molecular Function	DNA Binding Endonuclease Activity Protein Binding Metal Ion Binding	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Catabolic Process, Endonucleolytic DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		4 interactors: APP MUS81 SLX1A SLX4	5 interactors: CHEK2 EME1 EME2 SLX1A SLX4
Entrez ID		146956	80198
HPRD ID		10937	09419
Ensembl ID		ENSG00000154920	ENSG00000172732
Uniprot IDs		Q96AY2	Q53ES5 Q96NY9
PDB IDs		2ZIU 2ZIV 2ZIW 2ZIX	2MC3 2ZIX
Enriched GO Terms of Interacting Partners?		DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Response To Intra-S DNA Damage Checkpoint Signaling DNA Catabolic Process, Endonucleolytic DNA Double-strand Break Processing DNA Catabolic Process DNA Recombination Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process DNA Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Double-strand Break Repair Synaptic Growth At Neuromuscular Junction DNA Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stress Axon Choice Point Recognition Nucleobase-containing Compound Metabolic Process Neuron Remodeling Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Response To Biotic Stimulus Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating	DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleic Acid Phosphodiester Bond Hydrolysis Response To Intra-S DNA Damage Checkpoint Signaling DNA Metabolic Process DNA Double-strand Break Processing Cellular Response To Stress Double-strand Break Repair DNA Catabolic Process, Exonucleolytic Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Catabolic Process, Endonucleolytic Signal Transduction Involved In Intra-S DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Catabolic Process Nitrogen Compound Metabolic Process Cellular Response To Stimulus Regulation Of Nuclear Cell Cycle DNA Replication Intra-S DNA Damage Checkpoint DNA Damage Induced Protein Phosphorylation Aromatic Compound Catabolic Process Replicative Senescence Catabolic Process Mitotic Spindle Assembly Response To Stimulus Mitotic Spindle Organization Response To Biotic Stimulus Negative Regulation Of DNA Replication Response To Gamma Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Metabolic Process Cell Aging Spindle Assembly Protein Stabilization Signal Transduction In Response To DNA Damage Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint
Tagcloud ?		accordingly alleles break breaks carrying cytotoxic depleted disrupted disruption double eliminate endonucleolytic es excessive extensive fbh1 forks helicase hydroxyurea killing malignancies mediating mus81 nuclease occurring operates promoting replication strand	adjacent analyze chinese clinicopathological colorectal correlated correlation correlations corresponding distant explore han marker markers metastasis nested normal parameters pattern profile progression quantitative real stage suggesting tissues tnm tumor value
Tagcloud (Difference) ?		accordingly alleles break breaks carrying cytotoxic depleted disrupted disruption double eliminate endonucleolytic es excessive extensive fbh1 forks helicase hydroxyurea killing malignancies mediating nuclease occurring operates promoting replication strand	adjacent analyze chinese clinicopathological colorectal correlated correlation correlations corresponding distant explore han marker markers metastasis nested normal parameters pattern profile progression quantitative real stage suggesting tissues tnm tumor value
Tagcloud (Intersection) ?		mus81