EME1 and MUS81

Number of citations of the paper that reports this interaction (PubMedID 12721304)
0

Data Source:
HPRD (in vitro)

		EME1	MUS81
Description		essential meiotic structure-specific endonuclease 1	MUS81 structure-specific endonuclease subunit
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GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Heterochromatin Nucleus Nucleoplasm Nucleolus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex
	Molecular Function	DNA Binding Nuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Metal Ion Binding	DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity DNA Endonuclease Activity, Producing 3'-phosphomonoesters Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Mitotic Recombination Intermediates Response To Intra-S DNA Damage Checkpoint Signaling	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Break-induced Replication DNA Repair Double-strand Break Repair DNA Catabolic Process DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Osteoblast Proliferation Resolution Of Mitotic Recombination Intermediates Response To Intra-S DNA Damage Checkpoint Signaling
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Breast cancer ( 23535729)
Interacting Genes		6 interacting genes: APP DDB1 MUS81 SLX1A SLX4 SUMO2	10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1
Entrez ID		146956	80198
HPRD ID		10937	09419
Ensembl ID		ENSG00000154920	ENSG00000172732
Uniprot IDs		Q96AY2	Q53ES5 Q96NY9
PDB IDs		2ZIU 2ZIV 2ZIW 2ZIX 4P0P 4P0Q 4P0R 4P0S 9F98 9F99 9F9A 9F9K 9F9L 9F9M	2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S 6VWB 7BU5 7F6L 9F98 9F99 9F9A 9F9K 9F9L 9F9M
Enriched GO Terms of Interacting Partners?		Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Positive Regulation Of T-circle Formation Slx1-Slx4 Complex Response To DNA Damage Checkpoint Signaling DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Crossover Junction DNA Endonuclease Activity Telomeric D-loop Disassembly Telomeric Loop Disassembly T-circle Formation Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Repair Resolution Of Meiotic Recombination Intermediates Chromosome, Telomeric Region DNA Double-strand Break Processing Positive Regulation Of Protein Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair DNA Metabolic Process DNA Recombination DNA Damage Response Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Nucleotide-excision Repair Chromosome Organization Regulation Of Protein Catabolic Process Meiosis I Cell Cycle Process Endonuclease Activity Positive Regulation Of Telomere Maintenance Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Negative Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Reproductive Process Macromolecule Metabolic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Positive Regulation Of Catabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Nuclease Activity	Double-strand Break Repair DNA Repair DNA Metabolic Process DNA Damage Response DNA Recombination Holliday Junction Resolvase Complex Cellular Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Nucleic Acid Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Meiotic Recombination Intermediates DNA Damage Checkpoint Signaling Telomere Maintenance Nucleobase-containing Compound Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Slx1-Slx4 Complex Signal Transduction In Response To DNA Damage Positive Regulation Of T-circle Formation Response To Intra-S DNA Damage Checkpoint Signaling Endodeoxyribonuclease Complex Response To Stress Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Resolution Of Mitotic Recombination Intermediates Negative Regulation Of Cell Cycle Phase Transition Response To DNA Damage Checkpoint Signaling DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Mitotic DNA Damage Checkpoint Signaling Organelle Organization Meiosis I Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Telomeric D-loop Disassembly Resolution Of DNA Recombination Intermediates Negative Regulation Of Cell Cycle Process Membraneless Organelle Assembly Nucleoplasm Telomeric Loop Disassembly Spindle Assembly T-circle Formation Regulation Of Cell Cycle Process PML Body Chromosome Organization Negative Regulation Of Cell Cycle Nuclease Activity Regulation Of Protein Catabolic Process Nucleus
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