EME1 and SLX1A

Number of citations of the paper that reports this interaction (PubMedID 19595721)
0

Data Source:
BioGRID (pull down)

		EME1	SLX1A
Description		essential meiotic structure-specific endonuclease 1	structure-specific endonuclease subunit SLX1A
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Heterochromatin Nucleus Nucleoplasm Nucleolus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex	Nucleus Nucleoplasm Slx1-Slx4 Complex
	Molecular Function	DNA Binding Nuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Metal Ion Binding	Nuclease Activity Endonuclease Activity Protein Binding Zinc Ion Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity 5'-flap Endonuclease Activity Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Mitotic Recombination Intermediates Response To Intra-S DNA Damage Checkpoint Signaling	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: APP DDB1 MUS81 SLX1A SLX4 SUMO2	6 interacting genes: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4
Entrez ID		146956	548593
HPRD ID		10937	18681
Ensembl ID		ENSG00000154920	ENSG00000132207
Uniprot IDs		Q96AY2	Q9BQ83
PDB IDs		2ZIU 2ZIV 2ZIW 2ZIX 4P0P 4P0Q 4P0R 4P0S 9F98 9F99 9F9A 9F9K 9F9L 9F9M
Enriched GO Terms of Interacting Partners?		Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Positive Regulation Of T-circle Formation Slx1-Slx4 Complex Response To DNA Damage Checkpoint Signaling DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Crossover Junction DNA Endonuclease Activity Telomeric D-loop Disassembly Telomeric Loop Disassembly T-circle Formation Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Repair Resolution Of Meiotic Recombination Intermediates Chromosome, Telomeric Region DNA Double-strand Break Processing Positive Regulation Of Protein Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair DNA Metabolic Process DNA Recombination DNA Damage Response Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Nucleotide-excision Repair Chromosome Organization Regulation Of Protein Catabolic Process Meiosis I Cell Cycle Process Endonuclease Activity Positive Regulation Of Telomere Maintenance Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Negative Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Reproductive Process Macromolecule Metabolic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Positive Regulation Of Catabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Nuclease Activity	Resolution Of Meiotic Recombination Intermediates ERCC4-ERCC1 Complex Telomere Maintenance Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Telomere Organization Response To DNA Damage Checkpoint Signaling Double-strand Break Repair DNA Recombination Meiosis I Cell Cycle Process DNA Damage Response Chromosome Organization DNA Repair Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Negative Regulation Of Protection From Non-homologous End Joining At Telomere Nucleotide-excision Repair Positive Regulation Of T-circle Formation Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Cellular Response To Stress Endodeoxyribonuclease Complex DNA Metabolic Process Resolution Of Mitotic Recombination Intermediates Nucleotide-excision Repair Complex Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Capping Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding Regulation Of Telomere Maintenance T-circle Formation UV Protection Nuclease Activity Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Recombination Regulation Of Telomere Capping Double-strand Break Repair Via Homologous Recombination Organelle Organization Recombinational Repair Signal Transduction In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Reproductive Process Mitotic Recombination Nuclear Replication Fork Cellular Response To Radiation DNA Endonuclease Activity
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