EME1 and SLX1A

Number of citations of the paper that reports this interaction (PMID 19595721)
86

Data Source:
BioGRID (pull down)

		EME1	SLX1A
Gene Name		essential meiotic structure-specific endonuclease 1	SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Heterochromatin Nucleolus Cytoplasm	Slx1-Slx4 Complex
	Molecular Function	DNA Binding Endonuclease Activity Protein Binding Metal Ion Binding	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding
	Biological Process	DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP MUS81 SLX1A SLX4	6 interactors: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4
Entrez ID		146956	548593
HPRD ID		10937	18681
Ensembl ID		ENSG00000154920	ENSG00000132207
Uniprot IDs		Q96AY2	Q9BQ83
PDB IDs		2ZIU 2ZIV 2ZIW 2ZIX
Enriched GO Terms of Interacting Partners?		DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Response To Intra-S DNA Damage Checkpoint Signaling DNA Catabolic Process, Endonucleolytic DNA Double-strand Break Processing DNA Catabolic Process DNA Recombination Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process DNA Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Double-strand Break Repair Synaptic Growth At Neuromuscular Junction DNA Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stress Axon Choice Point Recognition Nucleobase-containing Compound Metabolic Process Neuron Remodeling Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Response To Biotic Stimulus Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating	Response To Intra-S DNA Damage Checkpoint Signaling DNA Recombination Cellular Response To DNA Damage Stimulus Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process, Endonucleolytic DNA Catabolic Process DNA Repair Cellular Response To Stress Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision DNA Metabolic Process Nucleotide-excision Repair Interstrand Cross-link Repair Aromatic Compound Catabolic Process Negative Regulation Of Telomere Maintenance UV Protection Double-strand Break Repair Nucleotide-excision Repair, DNA Damage Removal Regulation Of Telomere Maintenance Response To Stress Cellular Macromolecule Catabolic Process Transcription-coupled Nucleotide-excision Repair Response To Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Catabolic Process Response To UV Cellular Response To Stimulus Response To Ionizing Radiation Response To Biotic Stimulus Post-embryonic Hemopoiesis DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Shortening Pyrimidine Dimer Repair By Nucleotide-excision Repair Regulation Of Organelle Organization Regulation Of Chromosome Organization Nucleobase-containing Compound Metabolic Process Replicative Cell Aging Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stimulus Response To Abiotic Stimulus DNA Double-strand Break Processing Cellular Nitrogen Compound Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Aging
Tagcloud ?		accordingly alleles break breaks carrying cytotoxic depleted disrupted disruption double eliminate endonucleolytic es excessive extensive fbh1 forks helicase hydroxyurea killing malignancies mediating mus81 nuclease occurring operates promoting replication strand
Tagcloud (Difference) ?		accordingly alleles break breaks carrying cytotoxic depleted disrupted disruption double eliminate endonucleolytic es excessive extensive fbh1 forks helicase hydroxyurea killing malignancies mediating mus81 nuclease occurring operates promoting replication strand
Tagcloud (Intersection) ?