EME1

Description		essential meiotic structure-specific endonuclease 1
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GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Heterochromatin Nucleus Nucleoplasm Nucleolus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex
	Molecular Function	DNA Binding Nuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Mitotic Recombination Intermediates Response To Intra-S DNA Damage Checkpoint Signaling
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS
Interacting Genes		6 interacting genes: APP DDB1 MUS81 SLX1A SLX4 SUMO2
Entrez ID		146956
HPRD ID		10937
Ensembl ID		ENSG00000154920
Uniprot IDs		Q96AY2
PDB IDs		2ZIU 2ZIV 2ZIW 2ZIX 4P0P 4P0Q 4P0R 4P0S 9F98 9F99 9F9A 9F9K 9F9L 9F9M
Enriched GO Terms of Interacting Partners?		Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Positive Regulation Of T-circle Formation Slx1-Slx4 Complex Response To DNA Damage Checkpoint Signaling DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Crossover Junction DNA Endonuclease Activity Telomeric D-loop Disassembly Telomeric Loop Disassembly T-circle Formation Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Repair Resolution Of Meiotic Recombination Intermediates Chromosome, Telomeric Region DNA Double-strand Break Processing Positive Regulation Of Protein Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair DNA Metabolic Process DNA Recombination DNA Damage Response Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Nucleotide-excision Repair Chromosome Organization Regulation Of Protein Catabolic Process Meiosis I Cell Cycle Process Endonuclease Activity Positive Regulation Of Telomere Maintenance Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Negative Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Reproductive Process Macromolecule Metabolic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Positive Regulation Of Catabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Nuclease Activity
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