EME1

Gene Name		essential meiotic structure-specific endonuclease 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Heterochromatin Nucleolus Cytoplasm
	Molecular Function	DNA Binding Endonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: APP MUS81 SLX1A SLX4
Entrez ID		146956
HPRD ID		10937
Ensembl ID		ENSG00000154920
Uniprot IDs		Q96AY2
PDB IDs		2ZIU 2ZIV 2ZIW 2ZIX
Enriched GO Terms of Interacting Partners?		DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Response To Intra-S DNA Damage Checkpoint Signaling DNA Catabolic Process, Endonucleolytic DNA Double-strand Break Processing DNA Catabolic Process DNA Recombination Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process DNA Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Double-strand Break Repair Synaptic Growth At Neuromuscular Junction DNA Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stress Axon Choice Point Recognition Nucleobase-containing Compound Metabolic Process Neuron Remodeling Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Response To Biotic Stimulus Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating
Tagcloud ?		accordingly alleles break breaks carrying cytotoxic depleted disrupted disruption double eliminate endonucleolytic es excessive extensive fbh1 forks helicase hydroxyurea killing malignancies mediating mus81 nuclease occurring operates promoting replication strand