CFAP52 and BRCA2

Number of citations of the paper that reports this interaction (PubMedID 15967112)
37

Data Source:
HPRD (in vivo)

		CFAP52	BRCA2
Description		cilia and flagella associated protein 52	BRCA2 DNA repair associated
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Sperm Midpiece 9+2 Motile Cilium Axonemal B Tubule Inner Sheath	Nuclear Ubiquitin Ligase Complex Chromosome, Telomeric Region Lateral Element Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Secretory Granule Protein-containing Complex BRCA2-MAGE-D1 Complex DNA Repair Complex
	Molecular Function	Protein Binding	Protease Binding DNA Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding Histone H3 Acetyltransferase Activity Histone H4 Acetyltransferase Activity Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Spermatogenesis Spermatid Development Single Fertilization Gene Expression Flagellated Sperm Motility Microtubule Sliding Establishment Of Left/right Asymmetry	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Male Meiosis I Spermatogenesis Brain Development Cell Population Proliferation Female Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis DNA Damage Response, Signal Transduction By P53 Class Mediator Replication Fork Processing Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Chordate Embryonic Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Chromosome Organization Centrosome Duplication Establishment Of Protein Localization To Telomere Hematopoietic Stem Cell Proliferation Cellular Response To Ionizing Radiation Stem Cell Proliferation Cellular Senescence Mitotic Recombination-dependent Replication Fork Processing Regulation Of DNA Damage Checkpoint
Pathways			HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 translocation to the nucleus Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Impaired BRCA2 binding to SEM1 (DSS1)
Drugs
Diseases			Ovarian cancer Fanconi anemia Breast cancer Pancreatic cancer
GWAS			Apolipoprotein B levels ( 32203549) Basal cell carcinoma ( 31174203) Breast cancer ( 23535733 23535729 29059683) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol ( 24097068) LDL cholesterol levels ( 32203549 28334899) Lung cancer ( 28604730 24880342) Lung cancer in ever smokers ( 28604730) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		3 interacting genes: BRCA2 CCT4 HSPA1A	47 interacting genes: ATR BCCIP BRCA1 BUB1B CCNA1 CCNA2 CCND1 CCNE1 CDK1 CDK2 CFAP52 CHEK1 CHEK2 DMC1 DYNC1LI1 DYNC1LI2 EMSY ERCC5 FANCD2 FANCE FANCG FANCI FLNA H2AX HMG20B HNRNPC KAT2B LIMD1 MAGED1 PALB2 PDS5B PLEC PLK1 RAD51 RNASEH2A RPA1 SEM1 SERPINH1 SMAD3 STAT5A TP53 TP53BP1 UQCC1 USP11 USP21 WTIP XPO1
Entrez ID		146845	675
HPRD ID		14072	02554
Ensembl ID		ENSG00000166596	ENSG00000139618
Uniprot IDs		Q8N1V2	A0A7P0T9D7 A0A8V8TPZ2 P51587
PDB IDs		7UNG 8J07	1N0W 3EU7 6GY2 6HQU 7BDX 7LDG 8BR9 8C3J 8C3N 8PBC 8PBD 8QQE 8R2G 8UVW
Enriched GO Terms of Interacting Partners?		ATP-dependent Protein Folding Chaperone Protein Folding Chaperone Centrosome Unfolded Protein Binding BRCA2-MAGE-D1 Complex Mitotic Recombination-dependent Replication Fork Processing Denatured Protein Binding Protein Folding Nuclear Ubiquitin Ligase Complex Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Histone H3 Acetyltransferase Activity Cytoskeleton Establishment Of Protein Localization To Telomere Regulation Of Protein Stability ATP Hydrolysis Activity C3HC4-type RING Finger Domain Binding Protein Stabilization Death Receptor Agonist Activity ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Microtubule Nucleation Cellular Heat Acclimation Zona Pellucida Receptor Complex ScaRNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Histone H4 Acetyltransferase Activity Negative Regulation Of Inclusion Body Assembly Regulation Of Telomerase RNA Localization To Cajal Body Regulation Of Cellular Response To Stress Lateral Element Telomere Maintenance Via Recombination Regulation Of Mammary Gland Epithelial Cell Proliferation Inner Cell Mass Cell Proliferation Response To UV-C DNA Repair Complex Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Organelle Organization Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Centrosome Duplication Mitotic Recombination Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Unfolded Protein Inclusion Body Misfolded Protein Binding Regulation Of Microtubule Nucleation Positive Regulation Of Biosynthetic Process Regulation Of Inclusion Body Assembly	DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Cellular Response To Stress Double-strand Break Repair Nucleoplasm Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition Response To Stress Mitotic DNA Damage Checkpoint Signaling Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Cell Cycle Phase Transition Nucleus Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Chromosome, Telomeric Region Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Chromosome Organization Recombinational Repair Response To Ionizing Radiation Cell Cycle G2/M Phase Transition Chromosome DNA Repair Complex Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Organelle Organization Regulation Of Cell Cycle G2/M Phase Transition Interstrand Cross-link Repair Regulation Of Mitotic Cell Cycle Phase Transition Condensed Nuclear Chromosome Centrosome DNA Recombination Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Chromosome Organization Cyclin A2-CDK2 Complex Response To Radiation Damaged DNA Binding
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