CFAP52 and BRCA2

Number of citations of the paper that reports this interaction (PMID 15967112)
6

Data Source:
HPRD (in vivo)

		CFAP52	BRCA2
Gene Name		cilia and flagella associated protein 52	breast cancer 2, early onset
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cell Projection	Nucleus Nucleoplasm Cytoplasm Centrosome Secretory Granule BRCA2-MAGE-D1 Complex Protein Complex
	Molecular Function	Protein Binding	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Gamma-tubulin Binding
	Biological Process		Double-strand Break Repair Via Homologous Recombination Cytokinesis Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication
Pathways			Homologous DNA pairing and strand exchange Meiotic recombination Fanconi Anemia pathway Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS			Breast cancer ( 23535729 23535733)
Protein-Protein Interactions		3 interactors: BRCA2 CCT4 HSPA1A	34 interactors: ATM ATR BCCIP BRCA1 BUB1B C11orf30 CCNA2 CCNE1 CDK1 CDK2 CFAP52 CHEK2 DMC1 FANCD2 FANCE FANCG FLNA H2AFX HMG20B HNRNPC KAT2B MAGED1 NEDD4 PALB2 PLK1 RAD51 RPA1 SERPINH1 SHFM1 SMAD3 STAT5A TP53 UQCC1 USP11
Entrez ID		146845	675
HPRD ID		14072	02554
Ensembl ID		ENSG00000166596	ENSG00000139618
Uniprot IDs		Q8N1V2	P51587
PDB IDs			1N0W 3EU7
Enriched GO Terms of Interacting Partners?		Cellular Heat Acclimation Protein Folding Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Replication Fork Protection Negative Regulation Of Inclusion Body Assembly Response To UV-C DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Inclusion Body Assembly Negative Regulation Of Cell Proliferation Protein Refolding Positive Regulation Of Erythrocyte Differentiation Inner Cell Mass Cell Proliferation Oocyte Maturation Sexual Reproduction Blastocyst Growth Regulation Of Cellular Response To Heat Male Meiosis I Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Centrosome Duplication Regulation Of Erythrocyte Differentiation Toxin Transport Viral Entry Into Host Cell Binding Of Sperm To Zona Pellucida Entry Into Host Cell Reproduction Histone H3 Acetylation Oocyte Development Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Oocyte Differentiation Negative Regulation Of DNA Replication Response To Abiotic Stimulus Cellular Protein Metabolic Process Sperm-egg Recognition Histone H4 Acetylation Response To Gamma Radiation Centrosome Cycle 'de Novo' Posttranslational Protein Folding Regulation Of Cytokinesis Single Organism Reproductive Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Male Meiosis 'de Novo' Protein Folding Cellular Response To Heat Cell-cell Recognition Reproductive Process Cell Aging Positive Regulation Of Myeloid Cell Differentiation	Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Repair DNA Metabolic Process Cell Cycle Checkpoint Cellular Response To Stress Regulation Of Protein Metabolic Process DNA Damage Checkpoint Double-strand Break Repair Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Recombination Chromosome Organization Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Stimulus Meiotic Cell Cycle Replicative Senescence Mitotic Cell Cycle Process G2 DNA Damage Checkpoint Cellular Response To Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Meiotic Nuclear Division Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Cell Aging Reproduction DNA Replication Cellular Metabolic Process
Tagcloud ?			185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1
Tagcloud (Difference) ?			185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1
Tagcloud (Intersection) ?