CFAP52 and CCT4

Number of citations of the paper that reports this interaction (PMID 15967112)
6

Data Source:
HPRD (in vivo)

		CFAP52	CCT4
Gene Name		cilia and flagella associated protein 52	chaperonin containing TCP1, subunit 4 (delta)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cell Projection	Zona Pellucida Receptor Complex Nucleoplasm Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Melanosome Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding ATP Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process		Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport
Pathways			Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: BRCA2 CCT4 HSPA1A	10 interactors: ACTA1 ACTA2 ACTB CCNE1 CFAP52 PRPF40A RFWD2 RPS6KA1 UBC VRK2
Entrez ID		146845	10575
HPRD ID		14072	05506
Ensembl ID		ENSG00000166596	ENSG00000115484
Uniprot IDs		Q8N1V2	B7Z2F4 P50991
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Heat Acclimation Protein Folding Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Replication Fork Protection Negative Regulation Of Inclusion Body Assembly Response To UV-C DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Inclusion Body Assembly Negative Regulation Of Cell Proliferation Protein Refolding Positive Regulation Of Erythrocyte Differentiation Inner Cell Mass Cell Proliferation Oocyte Maturation Sexual Reproduction Blastocyst Growth Regulation Of Cellular Response To Heat Male Meiosis I Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Centrosome Duplication Regulation Of Erythrocyte Differentiation Toxin Transport Viral Entry Into Host Cell Binding Of Sperm To Zona Pellucida Entry Into Host Cell Reproduction Histone H3 Acetylation Oocyte Development Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Oocyte Differentiation Negative Regulation Of DNA Replication Response To Abiotic Stimulus Cellular Protein Metabolic Process Sperm-egg Recognition Histone H4 Acetylation Response To Gamma Radiation Centrosome Cycle 'de Novo' Posttranslational Protein Folding Regulation Of Cytokinesis Single Organism Reproductive Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Male Meiosis 'de Novo' Protein Folding Cellular Response To Heat Cell-cell Recognition Reproductive Process Cell Aging Positive Regulation Of Myeloid Cell Differentiation	Cell Cycle Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Toll-like Receptor 4 Signaling Pathway Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Toll-like Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Positive Regulation Of Hepatic Stellate Cell Activation Signal Transduction By P53 Class Mediator Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Innate Immune Response-activating Signal Transduction Regulation Of Cell Cycle G1/S Phase Transition Response To Stimulus Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Immune Response Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Movement Of Cell Or Subcellular Component G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?			20s assist back carry cct5 chaperonin chaperonins cryo crystallin encapsulate gammad gradients hetero homo hydrolyzed individually oligomeric oligomers organized refolding rings sedimented stain sucrose tcp testes tric ubiquitous
Tagcloud (Difference) ?			20s assist back carry cct5 chaperonin chaperonins cryo crystallin encapsulate gammad gradients hetero homo hydrolyzed individually oligomeric oligomers organized refolding rings sedimented stain sucrose tcp testes tric ubiquitous
Tagcloud (Intersection) ?