MGAT5B and RTN4R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MGAT5B	RTN4R
Description		alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	reticulon 4 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Axon Dendrite Growth Cone Cell Projection Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome Side Of Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Transferase Activity Glycosyltransferase Activity Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Manganese Ion Binding Metal Ion Binding	Protein Binding Heparin Binding Lipid Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Ganglioside GM1 Binding Ganglioside GT1b Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation	Cell Surface Receptor Signaling Pathway Axonogenesis Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration Regulation Of Synapse Assembly Regulation Of Postsynapse Assembly
Pathways		DAG1 core M2 glycosylations	Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Cannabis use (initiation) ( 22823124) Colorectal or endometrial cancer ( 26621817) Early cardiac repolarization ( 22683750) Nicotine dependence symptom count ( 25555482) Pulmonary emphysema ( 24383474) Refractive error ( 32231278) Virologic severity in Herpes simplex virus type 2 infection ( 29535370)	Blood protein levels ( 30072576) Obesity-related traits ( 23251661)
Interacting Genes		112 interacting genes: ABHD11 ADAMTSL4 ADRA2C ANAPC11 ANTKMT ATG9A ATP23 BMF C10orf55 C17orf50 C22orf39 CAMK2B CD46 CFAP68 CFTR CIMIP2B CREB5 CSN3 CTAG1A CTAG1B CXCL5 CYSRT1 DMRT3 EIF4E2 EIF4ENIF1 FAM83A FNDC11 FOXH1 GATA1 GLYCTK GNE HIGD2B HOXA1 HOXC8 HR HSD3B7 HUNK IGLL5 IQCE IVD KCTD17 KLHL38 KPRP KRT86 KRTAP1-1 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP22-1 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 LASP1 LONRF1 MAGED1 MCCD1 MDFI MKRN3 MSX2 NHLRC4 OIP5 OTX1 PITX1 PLA2G10 PLSCR1 PTGER3 PTH1R PTPRZ1 R3HDM2 RBP3 RBPMS RHOXF2 RSKR RTN4R SLC16A5 SLC25A48 SMARCC1 SMUG1 SNRPC SPAG8 SSC4D STK16 SYNGAP1 TBX6 TEKT5 TENT5B TMEM42 TNS2 TRIM35 TRIM42 TRIP13 TSPAN4 TXNDC5 TYRO3 UBAP2 UNKL VAC14 ZIC1 ZNF20 ZNF414 ZNF581	9 interacting genes: HOXA1 LINGO1 MAG MGAT5B NGFR OMG OTX1 RTN4 RTN4IP1
Entrez ID		146664	65078
HPRD ID		14392	16123
Ensembl ID		ENSG00000167889	ENSG00000040608
Uniprot IDs		Q3V5L5	Q9BZR6
PDB IDs			1OZN 1P8T
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Keratin Filament	Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Cochlea Morphogenesis Blood Vessel Development Neuron Projection Regeneration Regulation Of Neuron Projection Development Negative Regulation Of Axon Extension Artery Development Semicircular Canal Formation Developmental Process Negative Regulation Of Axonogenesis Nervous System Development Diencephalon Morphogenesis Regulation Of Postsynapse Assembly Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Coreceptor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Abducens Nerve Formation Optokinetic Behavior Mesaxon Regulation Of Cell Projection Organization Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Regulation Of Axon Extension Ganglioside GT1b Binding Death Receptor Activity Metencephalon Development Positive Regulation Of Protein Localization To Endoplasmic Reticulum
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