CNTN2 and UBE4B

Number of citations of the paper that reports this interaction (PubMedID 33362245)
63

Data Source:
BioGRID (enzymatic study)

		CNTN2	UBE4B
Description		contactin 2	ubiquitination factor E4B
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Node Of Ranvier Neuron Projection Neuronal Cell Body Axon Initial Segment Myelin Sheath Juxtaparanode Region Of Axon Synapse Postsynaptic Membrane Side Of Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Protein Binding Carbohydrate Binding Cell Adhesion Mediator Activity Cell-cell Adhesion Mediator Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration G Protein-coupled Adenosine Receptor Signaling Pathway Response To Dietary Excess Reduction Of Food Intake In Response To Dietary Excess Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Axonal Fasciculation Learning Adult Walking Behavior Positive Regulation Of Protein Processing Protein Processing Cerebral Cortex GABAergic Interneuron Migration Central Nervous System Neuron Differentiation Central Nervous System Myelination Regulation Of Cell Morphogenesis Regulation Of Axon Diameter Neuron Projection Development Receptor Internalization Clustering Of Voltage-gated Potassium Channels Fat Cell Differentiation Negative Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Astrocyte Differentiation Synapse Organization Establishment Of Localization In Cell Positive Regulation Of Adenosine Receptor Signaling Pathway Dendrite Self-avoidance Protein Localization To Juxtaparanode Region Of Axon Establishment Of Protein Localization To Juxtaparanode Region Of Axon Presynaptic Membrane Organization	Protein Polyubiquitination Ventricular Trabecula Myocardium Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Granzyme-mediated Apoptotic Signaling Pathway Response To UV Protein Ubiquitination Protein Catabolic Process Neuron Projection Development Response To Endoplasmic Reticulum Stress ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		L1CAM interactions NCAM1 interactions NrCAM interactions
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) HDL cholesterol levels ( 32203549) Mean platelet volume ( 24026423) Meat-related diet ( 32066663) Number of sexual partners ( 30643258) Periodontitis (stage III/IV grade C) ( 33745150) Red blood cell count ( 27863252) Schizophrenia ( 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Atrial fibrillation ( 29892015) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin levels ( 33491795) Hepatocellular carcinoma ( 20676096) Hip circumference adjusted for BMI ( 34021172) Resting heart rate ( 27798624)
Interacting Genes		12 interacting genes: CDK4 CHEK1 CNTN1 CNTNAP2 EGFR L1CAM NCAN NFYB NRCAM TUBG1 UBE4B VAC14	27 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A CNTN2 DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 PYCR2 RAD23A RIPK4 TP53 TRA2A TRIP12 UBE2D2 UBE2D3 VAV2 VCP
Entrez ID		6900	10277
HPRD ID		01826	11659
Ensembl ID		ENSG00000184144	ENSG00000130939
Uniprot IDs		A1L3A3 Q02246	O95155
PDB IDs		2OM5 8K3J 8K53 9BA4 9BA5	2KRE 3L1X 3L1Z 5O75
Enriched GO Terms of Interacting Partners?		Condensed Nuclear Chromosome Regulation Of Mitotic Centrosome Separation Neuron Projection Development Cell Adhesion Neuronal Ion Channel Clustering Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Axon Central Nervous System Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Cell-cell Adhesion Mediator Activity Plasma Membrane Bounded Cell Projection Organization Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cell-cell Adhesion Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Neuron Projection Guidance Axon Guidance Neuron Recognition Brain Development Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Centriole-centriole Cohesion Nuclear Chromosome Segregation Granzyme-mediated Apoptotic Signaling Pathway PAS Complex Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Process Kinase Activity Cell Projection Organization Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Ciliary Basal Body Shc-EGFR Complex Microtubule Nucleator Activity Limbic System Development Superior Temporal Gyrus Development Regulation Of Axon Extension Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Protein Serine Kinase Activity Regulation Of Fibroblast Proliferation Histone H3T11 Kinase Activity Protein Phosphatase Binding Positive Regulation Of Protein Kinase C Signaling	Catabolic Process Cytosol Cellular Response To Staurosporine Proteolysis DNA Damage Response Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Nucleoplasm Response To Stress Pyroptotic Inflammatory Response Positive Regulation Of Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death DNA Repair Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Metabolic Process Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Post-translational Protein Modification Positive Regulation Of Neuron Apoptotic Process Nucleic Acid Metabolic Process Macroautophagy Apoptotic Process Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling TOR Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling DNA Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Response To Stress Regulation Of TORC1 Signaling Regulation Of Macromolecule Metabolic Process
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