GDF1 and HTR4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GDF1	HTR4
Description		growth differentiation factor 1	5-hydroxytryptamine receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Cytokine Activity Growth Factor Activity	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	In Utero Embryonic Development Signal Transduction Endoderm Development Mesoderm Development BMP Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly
Pathways		Signaling by NODAL	Serotonin receptors G alpha (s) signalling events
Drugs			Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases		Tetralogy of Fallot Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome
GWAS			Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 30804561 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010835 20010834) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)
Interacting Genes		1 interacting genes: HTR4	18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7
Entrez ID		2657	3360
HPRD ID		04194	09074
Ensembl ID		ENSG00000130283	ENSG00000164270
Uniprot IDs		P27539	A0A2D3FAF9 Q13639
PDB IDs			5EM9 7XT8 7XT9 7XTA
Enriched GO Terms of Interacting Partners?		Large Intestinal Transit Perineuronal Net Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Serotonin Binding G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Mucus Secretion Hyaluronic Acid Binding Neurotransmitter Receptor Activity Maintenance Of Gastrointestinal Epithelium G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Appetite Epithelial Structure Maintenance Regulation Of Postsynapse Assembly G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Body Fluid Secretion Digestive System Process Lysosomal Lumen Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Golgi Lumen	Membrane Endoplasmic Reticulum Membrane
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