CRYBA1 and CHCHD2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CRYBA1	CHCHD2
Name		crystallin beta A1	coiled-coil-helix-coiled-coil-helix domain containing 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	None	Nucleus Mitochondrion Mitochondrial Intermembrane Space
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding	Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Cytokine Production Lens Development In Camera-type Eye Phagocytosis Visual Perception Regulation Of Autophagy Negative Regulation Of TOR Signaling Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Anoikis	Mitochondrion Organization Cellular Response To Oxidative Stress Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Hypoxia Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		None	Mitochondrial protein import Mitochondrial protein degradation
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Depression ( 29700475 ) Mean reticulocyte volume ( 32888494 ) Night sleep phenotypes ( 27126917 )	Macular telangiectasia type 2 ( 33654266 ) Metabolite levels ( 23823483 31628463 ) Plasma free amino acid levels ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 )
Novel Interactors		9 novel interactors: CPD EVI2A EVI2B FBXO3 KLK10 NF1 OMG SPRR1B TAF15	None recorded
Interacting Genes		24 interacting genes: ARID5A BANF2 CELF6 CERK CHCHD2 CRYAA CRYAB CRYBB1 CRYBB2 CRYBB3 CYSRT1 FOXH1 HOXC8 KRTAP11-1 KRTAP13-2 KRTAP13-3 LASP1 NOXA1 PLEKHF2 PROP1 RBPMS RHOXF2 VAC14 YPEL3	30 interacting genes: ADAMTSL4 ADRA2C CHCHD10 CRYBA1 CTAG1A CTAG1B CYSRT1 EHMT2 FBXO7 GOLGA2 IKZF3 INCA1 KRT31 KRT40 LHX4 MIF4GD OIP5 P4HB PBX4 PLEKHF2 REL RNF144B TCF4 TRAF2 TREX1 TRIM42 TRIM54 TSC1 USP54 ZMYND12
Entrez ID		1411	51142
HPRD ID		00429	09879
Ensembl ID		ENSG00000108255	ENSG00000106153
Uniprot IDs		P05813	Q9Y6H1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Structural Molecule Activity Tubulin Complex Assembly Negative Regulation Of Intracellular Transport	Identical Protein Binding