CRYBA1 and CERK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRYBA1	CERK
Description		crystallin beta A1	ceramide kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytoplasm Plasma Membrane Membrane
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding	Nucleotide Binding Magnesium Ion Binding Ceramide Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Negative Regulation Of Cytokine Production Lens Development In Camera-type Eye Phagocytosis Visual Perception Regulation Of Autophagy Negative Regulation Of TOR Signaling Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Anoikis	Lipid Metabolic Process Ceramide Metabolic Process Glycosphingolipid Biosynthetic Process
Pathways			Glycosphingolipid biosynthesis
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Mean reticulocyte volume ( 32888494) Night sleep phenotypes ( 27126917)	Aseptic loosening in total joint arthroplasty ( 31791832) Triglyceride levels ( 30108155)
Interacting Genes		24 interacting genes: ARID5A BANF2 CELF6 CERK CHCHD2 CRYAA CRYAB CRYBB1 CRYBB2 CRYBB3 CYSRT1 FOXH1 HOXC8 KRTAP11-1 KRTAP13-2 KRTAP13-3 LASP1 NOXA1 PLEKHF2 PROP1 RBPMS RHOXF2 VAC14 YPEL3	21 interacting genes: ALAS1 APP CRYBA1 CYSRT1 KRT34 KRTAP1-1 KRTAP10-3 KRTAP11-1 KRTAP19-1 KRTAP19-6 KRTAP3-1 KRTAP3-2 KRTAP6-2 KRTAP9-2 MTUS2 NBPF19 NHLRC4 NOTCH2NLA OIP5 PLEKHF2 TRIM42
Entrez ID		1411	64781
HPRD ID		00429	09878
Ensembl ID		ENSG00000108255	ENSG00000100422
Uniprot IDs		P05813	Q8TCT0
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Structural Molecule Activity Tubulin Complex Assembly Negative Regulation Of Intracellular Transport	Intermediate Filament Keratin Filament Structural Molecule Activity
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