CRYBA1 and EVI2B

Data Source: HiPPIP (Novel)

		CRYBA1	EVI2B
Name		crystallin beta A1	ecotropic viral integration site 2B
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	None	Plasma Membrane Membrane
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Lens Development In Camera-type Eye Phagocytosis Visual Perception Regulation Of Autophagy Negative Regulation Of TOR Signaling Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Anoikis	Positive Regulation Of Granulocyte Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Neutrophil Differentiation Regulation Of Cell Cycle Myeloid Cell Development Regulation Of Stem Cell Division
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Depression ( 29700475 ) Mean reticulocyte volume ( 32888494 ) Night sleep phenotypes ( 27126917 )	Brain morphology (MOSTest) ( 32665545 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 )
Novel Interactors		9 novel interactors: CPD EVI2A EVI2B FBXO3 KLK10 NF1 OMG SPRR1B TAF15	1 novel interactors: CRYBA1
Interacting Genes		24 interacting genes: ARID5A BANF2 CELF6 CERK CHCHD2 CRYAA CRYAB CRYBB1 CRYBB2 CRYBB3 CYSRT1 FOXH1 HOXC8 KRTAP11-1 KRTAP13-2 KRTAP13-3 LASP1 NOXA1 PLEKHF2 PROP1 RBPMS RHOXF2 VAC14 YPEL3	31 interacting genes: APOD AQP1 AQP3 BTN2A2 CDIPT CLN6 CNIH1 DESI1 DRAM1 FAM3C FUNDC2 GALNT15 GIMAP5 MYADML2 NINJ2 NSG1 PGRMC1 RTP2 SCAMP4 SLC2A5 SLC30A2 SLC38A7 SLC39A9 TMEM107 TMEM222 TMEM60 TMEM86B TRAF3IP3 TRAM1L1 UBIAD1 VAMP4
Entrez ID		1411	2124
HPRD ID		00429	08867
Ensembl ID		ENSG00000108255	ENSG00000185862
Uniprot IDs		P05813	P34910 Q9BRW1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Structural Molecule Activity Tubulin Complex Assembly Negative Regulation Of Intracellular Transport	Membrane Polyol Transmembrane Transport Renal Water Transport Renal Water Absorption Glycerol Transmembrane Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Lysosome Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Water Channel Activity Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Protein Binding Renal Water Homeostasis Lysosomal Membrane Establishment Of Protein Localization To Membrane Golgi Apparatus Endoplasmic Reticulum Negative Regulation Of Lipoprotein Lipid Oxidation Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Multicellular Organismal-level Water Homeostasis One-carbon Compound Transport Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Water Transport Fructose Import Across Plasma Membrane Zinc Ion Import Into Zymogen Granule Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Intracellular Zinc Ion Homeostasis Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Trans-Golgi Network Membrane CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Multivesicular Body Membrane Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity D-lysine 5,6-aminomutase Activity