STK35 and PDLIM1

Number of citations of the paper that reports this interaction (PubMedID 11973348)
0

Data Source:
HPRD (two hybrid, in vitro)

		STK35	PDLIM1
Description		serine/threonine kinase 35	PDZ and LIM domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Body	Stress Fiber Transcription Regulator Complex Cytoplasm Cytoskeleton Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Transcription Coactivator Activity Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of G2/MI Transition Of Meiotic Cell Cycle	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Heart Development Fibroblast Migration Maintenance Of Cell Polarity Actin Cytoskeleton Organization Establishment Or Maintenance Of Actin Cytoskeleton Polarity Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Muscle Structure Development Cell-cell Adhesion
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Basal cell carcinoma ( 33549134) Early spontaneous preterm birth ( 31194736) Immune response to measles-mumps-rubella vaccine ( 24811271) Keratoconus ( 33649486) Plateletcrit ( 32888494) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Hemoglobin ( 32888494) Mean platelet volume ( 27863252 32888494) Suicide risk ( 21041247) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: BMPR1B OSBPL3 PDLIM1 SMAD4 SMURF1 TGFBR1	16 interacting genes: ACTN1 ACTN2 ACTN4 AGK GABARAPL2 GFAP MAP1LC3C MAPK6 PGS1 PITX2 PTGER4 RLIM RPS6KA5 STK35 SUPT4H1 VIM
Entrez ID		140901	9124
HPRD ID		11612	09326
Ensembl ID		ENSG00000125834	ENSG00000107438
Uniprot IDs		Q8TDR2	O00151 V9HW92
PDB IDs			1X62 2PKT
Enriched GO Terms of Interacting Partners?		SMAD Binding I-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I BMP Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Transmembrane Receptor Protein Serine/threonine Kinase Activity Ameboidal-type Cell Migration Regulation Of Extracellular Matrix Assembly Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Extracellular Matrix Organization R-SMAD Binding Cardiac Epithelial To Mesenchymal Transition Cellular Response To BMP Stimulus Activin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Regionalization Ventricular Septum Morphogenesis Neuron Fate Commitment Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Ventricular Cardiac Muscle Tissue Morphogenesis Response To Growth Factor Regulation Of Chondrocyte Differentiation Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Cellular Response To Transforming Growth Factor Beta Stimulus Pattern Specification Process Regulation Of SMAD Protein Signal Transduction Regulation Of Extracellular Matrix Organization Regulation Of Cell Growth Response To Transforming Growth Factor Beta Regulation Of Cartilage Development Cardiac Septum Morphogenesis Muscle Tissue Morphogenesis Roof Of Mouth Development Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Engulfment Of Target By Autophagosome Epithelial To Mesenchymal Transition Positive Regulation Of Developmental Process Animal Organ Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Differentiation	Pseudopodium Muscle Cell Development Integrin Binding Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Cortical Actin Cytoskeleton Bergmann Glial Cell Differentiation Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Cell Development Astrocyte Development Z Disc Transmembrane Transporter Binding Focal Adhesion Assembly Astrocyte Differentiation Organelle Organization Actin Filament Binding Positive Regulation Of Ion Transmembrane Transporter Activity Focal Adhesion Cell Junction Positive Regulation Of Transporter Activity Positive Regulation Of Macromolecule Biosynthetic Process Cell-substrate Junction Organization Cell-substrate Junction Assembly Cardiac Cell Development Actin Filament Uncapping Cardiac Muscle Cell Development Intermediate Filament Cytoskeleton Superior Vena Cava Morphogenesis Subthalamic Nucleus Development Negative Regulation Of Eosinophil Extravasation Histone H2AS1 Kinase Activity CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Activity Autophagosome Maturation Acylglycerol Kinase Activity Autophagosome Membrane Sarcomere Mitophagy Positive Regulation Of Biosynthetic Process Cytoskeleton Organization Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Postsynapse Titin Z Domain Binding Glial Cell Development Left Lung Morphogenesis Prolactin Secreting Cell Differentiation Cell Proliferation Involved In Outflow Tract Morphogenesis Pulmonary Vein Morphogenesis Septin Cytoskeleton
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