DYNLL2 and KIF2B

		DYNLL2	KIF2B
Description		dynein light chain LC8-type 2	kinesin family member 2B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding	Nucleotide Binding Microtubule Motor Activity ATP Binding Microtubule Binding ATP Hydrolysis Activity
	Biological Process	Microtubule-based Process	Microtubule-based Movement Microtubule Depolymerization Cell Division Metaphase Chromosome Alignment Regulation Of Chromosome Segregation
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Adult body size ( 32376654) Carotid intima media thickness x smoking interaction ( 32117412) Metabolite levels ( 23823483) Photic sneeze reflex ( 27182965) Type 2 diabetes ( 30297969)
Interacting Genes		30 interacting genes: BMF C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 IHO1 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 REDIC1 SKAP1 SMCP SPAG8 THAP10 TPPP XIAP ZAR1	1 interacting genes: STAU1
Entrez ID		140735	84643
HPRD ID		06489	10053
Ensembl ID		ENSG00000264364	ENSG00000141200
Uniprot IDs		Q96FJ2	A0A140VKG5 Q8N4N8
PDB IDs		2XQQ 3P8M 4D07 7CNU
Enriched GO Terms of Interacting Partners?		Microtubule Binding	Microtubule Associated Complex Myosin V Complex Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex LncRNA-mediated Post-transcriptional Gene Silencing Positive Regulation By Virus Of Viral Protein Levels In Host Cell Glutamatergic Synapse Anterograde Dendritic Transport Intracellular MRNA Localization 9+0 Non-motile Cilium Modification Of Postsynaptic Structure Dendritic Transport Positive Regulation Of Long-term Synaptic Potentiation Modification Of Synaptic Structure Microtubule-based Process Cytoplasmic Dynein Complex Protein Phosphatase 1 Binding Dendrite Cytoplasm Rough Endoplasmic Reticulum RNA Localization Positive Regulation Of Viral Genome Replication Dynein Intermediate Chain Binding Dynein Complex Regulation Of Long-term Synaptic Potentiation Ciliary Tip Protein Localization To Synapse Positive Regulation Of Viral Process Double-stranded RNA Binding Regulation Of Viral Genome Replication Protein Localization To Cell Junction Cell Body Cytoplasmic Ribonucleoprotein Granule Axo-dendritic Transport Scaffold Protein Binding Cytoplasmic Stress Granule Regulation Of Viral Life Cycle
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