DYNLL2 and C17orf67

		DYNLL2	C17orf67
Description		dynein light chain LC8-type 2	chromosome 17 open reading frame 67
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse	Extracellular Region
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding	Protein Binding
	Biological Process	Microtubule-based Process
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Adult body size ( 32376654) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Early spontaneous preterm birth ( 31194736) Estimated glomerular filtration rate ( 31152163) Height ( 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Nonsyndromic cleft lip with cleft palate ( 28232668) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		30 interacting genes: BMF C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 IHO1 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 REDIC1 SKAP1 SMCP SPAG8 THAP10 TPPP XIAP ZAR1	2 interacting genes: CADPS GOPC
Entrez ID		140735	339210
HPRD ID		06489	19273
Ensembl ID		ENSG00000264364	ENSG00000214226
Uniprot IDs		Q96FJ2	Q0P5P2
PDB IDs		2XQQ 3P8M 4D07 7CNU
Enriched GO Terms of Interacting Partners?		Microtubule Binding	Negative Regulation Of Anion Channel Activity Myosin V Complex Neuronal Dense Core Vesicle Membrane Postsynaptic Density Dense Core Granule Exocytosis Glutamatergic Synapse Negative Regulation Of Protein Localization To Cell Surface Regulation Of Monoatomic Anion Transport Molecular Sequestering Activity Golgi-associated Vesicle Membrane Trans-Golgi Network Transport Vesicle Apical Protein Localization 9+0 Non-motile Cilium Secretory Granule Localization Cytoplasmic Dynein Complex Negative Regulation Of Transporter Activity Calcium-ion Regulated Exocytosis Synaptic Vesicle Exocytosis Dynein Intermediate Chain Binding Dynein Complex Microtubule Associated Complex Regulation Of Protein Localization To Cell Surface Ciliary Tip Synapse Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Scaffold Protein Binding Positive Regulation Of Exocytosis Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Vesicle-mediated Transport In Synapse Establishment Of Protein Localization Regulated Exocytosis Establishment Of Vesicle Localization Negative Regulation Of Monoatomic Ion Transport Post-Golgi Vesicle-mediated Transport
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