NRL and EDF1

Number of citations of the paper that reports this interaction (PubMedID 16880509)
58

Data Source:
BioGRID (pull down)

		NRL	EDF1
Description		neural retina leucine zipper	endothelial differentiation related factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Leucine Zipper Domain Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	TFIID-class Transcription Factor Complex Binding DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Calmodulin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Visual Perception Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Retinal Rod Cell Development	Regulation Of DNA-templated Transcription Regulation Of Lipid Metabolic Process Cell Differentiation Positive Regulation Of DNA Binding Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		7 interacting genes: CRX EDF1 FIZ1 MAPK1 MAPK14 NR2E3 UBR5	23 interacting genes: ATF1 ATF2 CALM1 CALM2 CALM3 CDC42 CEBPA CFTR CREB1 JUN MAPK6 MEOX2 NR1H3 NR5A1 NR5A2 NRL PPARG PRKCA RXRA SOX4 TAF1 TBP UBE2I
Entrez ID		4901	8721
HPRD ID		08875	09235
Ensembl ID		ENSG00000129535	ENSG00000107223
Uniprot IDs		P54845	O60869
PDB IDs			1X57 6ZVH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Retina Development In Camera-type Eye Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Protein Transport Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cytosine Metabolic Process Nuclear Receptor-mediated Signaling Pathway Heterochromatin Boundary Formation Regulation Of Cellular Localization Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Ossification Regulation Of Nucleocytoplasmic Transport Response To Tumor Necrosis Factor Ficolin-1-rich Granule Lumen Regulation Of Synaptic Membrane Adhesion Interleukin-34-mediated Signaling Pathway Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Hormone-mediated Signaling Pathway Regulation Of Golgi Inheritance Cytoplasm Protein Quality Control	RNA Polymerase II Transcription Regulator Complex Chromatin MRNA Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity MRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Intracellular Signaling Cassette Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Calcineurin-mediated Signaling Positive Regulation Of RNA Metabolic Process Enzyme Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Transcription Coregulator Binding Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor Activity Positive Regulation Of Biosynthetic Process Double-stranded DNA Binding Developmental Process Neural Nucleus Development Transcription Regulator Complex Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Leukocyte Differentiation Sequence-specific Double-stranded DNA Binding Nucleoplasm Myeloid Leukocyte Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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