MAGEE2 and PCGF6

Number of citations of the paper that reports this interaction (PubMedID 25590999)
60

Data Source:
BioGRID (two hybrid)

		MAGEE2	PCGF6
Description		MAGE family member E2	polycomb group ring finger 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Brain Development Brain Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways			Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Potassium levels ( 29403010)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 23974872 25056061 29483656)
Interacting Genes		2 interacting genes: MNAT1 PCGF6	27 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 MYC OGT PEX10 PNMA1 RAD18 RNF2 SS18L1 TRIM14 TRIM55 TRIM63 TULP3 UBE2D3 UBE2U USP2 USP21
Entrez ID		139599	84108
HPRD ID		06585	07427
Ensembl ID		ENSG00000186675	ENSG00000156374
Uniprot IDs		Q8TD90	Q9BYE7
PDB IDs			2DJB
Enriched GO Terms of Interacting Partners?		CAK-ERCC2 Complex Transcription Factor TFIIK Complex Transcription Factor TFIIH Core Complex Adult Heart Development Transcription Factor TFIIH Holo Complex Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Ventricular System Development PRC1 Complex PcG Protein Complex Transcription Initiation At RNA Polymerase II Promoter Cyclin-dependent Protein Kinase Holoenzyme Complex	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription PRC1 Complex Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Post-translational Protein Modification Nucleus Negative Regulation Of RNA Metabolic Process PcG Protein Complex Regulation Of Primary Metabolic Process Chromatin Organization Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Ubiquitin Protein Ligase Activity Heterochromatin Protein Modification Process Protein Ubiquitination Regulation Of Metabolic Process RING-like Zinc Finger Domain Binding Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Protein Monoubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Body Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Chromatin Remodeling Protein Deubiquitination Chromosome Ubiquitin-protein Transferase Activity Macromolecule Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Protein Modification By Small Protein Removal Epigenetic Regulation Of Gene Expression Transferase Activity MLL1 Complex
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