SGCZ and DMD

Number of citations of the paper that reports this interaction (PMID 12189167)
12

Data Source:
HPRD (in vitro)

		SGCZ	DMD
Gene Name		sarcoglycan, zeta	dystrophin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Sarcoglycan Complex Integral Component Of Membrane Sarcolemma	Nucleus Cytosol Cytoskeleton Plasma Membrane Cell Surface Actin Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Lateral Plasma Membrane Cell Junction Filopodium Filopodium Membrane Sarcolemma Costamere Protein Complex Membrane Raft Postsynaptic Membrane
	Molecular Function		Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Nitric-oxide Synthase Binding
	Biological Process	Muscle Organ Development Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Muscle Cell Development Heart Contraction Membrane Organization	Regulation Of Heart Rate Muscle Organ Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Muscle Filament Sliding Extracellular Matrix Organization Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Peptide Biosynthetic Process Cellular Protein Complex Assembly Motile Cilium Assembly Positive Regulation Of Neuron Differentiation Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cardiac Muscle Cell Action Potential Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Peptidyl-cysteine S-nitrosylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Striated Muscle Contraction Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS		Methamphetamine dependence ( 23594818) Obesity-related traits ( 23251661) Platelet aggregation ( 20526338)	Response to antidepressant treatment ( 22041458)
Protein-Protein Interactions		2 interactors: DMD SGCB	27 interactors: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG HAUS1 KCNJ12 KRT19 KRT8 MAP3K5 PGM5 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 UTRN
Entrez ID		137868	1756
HPRD ID		12165	02303
Ensembl ID		ENSG00000185053	ENSG00000198947
Uniprot IDs		Q96LD1	A1L0U9 A7E212 P11532 Q16484 Q4G0X0
PDB IDs			1DXX 1EG3 1EG4 3UUN
Enriched GO Terms of Interacting Partners?		Muscle Fiber Development Striated Muscle Cell Development Muscle Cell Development Striated Muscle Cell Differentiation Muscle Organ Development Establishment Of Glial Blood-brain Barrier Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Establishment Of Blood-nerve Barrier Muscle Structure Development Olfactory Nerve Development Regulation Of Skeletal Muscle Contraction Neurotransmitter Receptor Metabolic Process Motile Cilium Assembly Vascular Smooth Muscle Cell Development Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Establishment Of Blood-brain Barrier Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Voltage-gated Calcium Channel Activity Vascular Smooth Muscle Cell Differentiation Anatomical Structure Arrangement Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Peptidyl-serine Phosphorylation Muscle Cell Cellular Homeostasis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Sodium Ion Transmembrane Transporter Activity Myotube Cell Development Peptide Biosynthetic Process Muscle Filament Sliding Actin-myosin Filament Sliding Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Cardiac Muscle Cell Action Potential Actin-mediated Cell Contraction Nucleus Localization Endothelial Cell Development Positive Regulation Of Ion Transmembrane Transporter Activity Cardiac Muscle Contraction Cranial Nerve Development Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Transporter Activity Smooth Muscle Cell Differentiation Myotube Differentiation Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport	Muscle Contraction Muscle System Process Muscle Cell Development Myofibril Assembly Actomyosin Structure Organization Organelle Assembly Cellular Component Assembly Muscle Structure Development Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Striated Muscle Cell Development Skeletal Myofibril Assembly Synaptic Vesicle Priming Striated Muscle Cell Differentiation Organ Development Cytoskeleton Organization Organelle Organization Muscle Organ Development Positive Regulation Of Proteolysis Cell Development System Development Positive Regulation Of Peptidase Activity Cell Differentiation Involved In Embryonic Placenta Development Actin-myosin Filament Sliding Muscle Filament Sliding Movement Of Cell Or Subcellular Component Regulation Of Sodium Ion Transmembrane Transport Microtubule-based Process Actin-mediated Cell Contraction Programmed Necrotic Cell Death Nerve Maturation Regulation Of Vasoconstriction By Circulating Norepinephrine Necrotic Cell Death Multicellular Organismal Development Sarcomere Organization Neuromuscular Junction Development Synaptic Vesicle Exocytosis Anatomical Structure Development Actin Filament-based Movement Cell-cell Signaling Heart Contraction Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Calcium-dependent Cell-matrix Adhesion Regulation Of Sodium Ion Transport Anatomical Structure Morphogenesis Viral Process Apoptotic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death
Tagcloud ?		boundaries cohorts definite disorder dystonia epsilon exon exons fifty heterogeneity hyperkinetic imprinted intron likelihood maternally movement myoclonus netherlands probable recruited sarcoglycan screened sgce subdivided suspected uk unlikely vary zeta	2gamma chromosome dffry encode escape escapes eutherian homologue homologues identity inactivation kangaroo maps metatherian primates retroposon retroposons shed simian smcy spermatogenesis sxrb ube1y ubiquitously uty xp21 y zfy1 zfy2
Tagcloud (Difference) ?		boundaries cohorts definite disorder dystonia epsilon exon exons fifty heterogeneity hyperkinetic imprinted intron likelihood maternally movement myoclonus netherlands probable recruited sarcoglycan screened sgce subdivided suspected uk unlikely vary zeta	2gamma chromosome dffry encode escape escapes eutherian homologue homologues identity inactivation kangaroo maps metatherian primates retroposon retroposons shed simian smcy spermatogenesis sxrb ube1y ubiquitously uty xp21 y zfy1 zfy2
Tagcloud (Intersection) ?