SGCZ and DMD

Number of citations of the paper that reports this interaction (PubMedID 12189167)
0

Data Source:
HPRD (in vitro)

		SGCZ	DMD
Description		sarcoglycan zeta	dystrophin
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Sarcoglycan Complex Membrane Sarcolemma	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Surface Actin Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Myofibril Z Disc Cell-substrate Junction Filopodium Filopodium Membrane Protein-containing Complex Sarcolemma Costamere Neuron Projection Terminus Membrane Raft Synapse Postsynaptic Membrane
	Molecular Function		Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Metal Ion Binding Nitric-oxide Synthase Binding
	Biological Process	Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Muscle Cell Development Heart Contraction Membrane Organization	Regulation Of Heart Rate Muscle Contraction Cytoskeleton Organization Muscle Organ Development Skeletal Muscle Tissue Development Intracellular Protein Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Maintenance Of Blood-brain Barrier Response To Muscle Stretch Peptide Biosynthetic Process Regulation Of System Process Motile Cilium Assembly Positive Regulation Of Neuron Differentiation Muscle Cell Cellular Homeostasis Neuron Development Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly Cardiac Muscle Cell Action Potential Regulation Of Muscle System Process Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Non-integrin membrane-ECM interactions Striated Muscle Contraction Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Golodirsen
Diseases			Dilated cardiomyopathy (DCM) Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Depressive symptom improvement ( 30468137) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Endometrial cancer (Non-endometrioid histology) ( 30093612) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Intelligence (MTAG) ( 29326435) Joint damage in rheumatoid arthritis ( 31596875) Methamphetamine dependence ( 23594818) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Platelet aggregation ( 20526338) Retinitis pigmentosa ( 33514863) Severe insulin-deficient type 2 diabetes ( 34737425) Small cell lung carcinoma ( 28604730) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Ankle-brachial index ( 31388106) Anxiety in major depressive disorder ( 24047446) Body mass index ( 28892062) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Major depressive disorder ( 34099189) Mild influenza (H1N1) infection ( 26379185) Response to anti-depressant treatment in major depressive disorder ( 22041458) Temporomandibular joint disorder ( 28081371) Waist circumference ( 28552196)
Interacting Genes		3 interacting genes: DMD SGCB SMIM3	32 interacting genes: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG FOXP1 HAUS1 HNF4A KCNJ12 KRT19 KRT8 MAP3K5 PGM5 PICK1 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 TRIM63 USP7 UTRN
Entrez ID		137868	1756
HPRD ID		12165	02303
Ensembl ID		ENSG00000185053	ENSG00000198947
Uniprot IDs		Q08AT0 Q96LD1	A0A087WV90 A0A0S2Z3B5 A0A0S2Z3J7 A0A5H1ZRP9 A0A5H1ZRQ1 A0A5H1ZRQ8 A0A5H1ZRR9 A0A804HKY9 A7E212 P11532 Q16484 Q4G0X0
PDB IDs			1DXX 1EG3 1EG4 3UUN 9D58
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Sarcolemma Muscle Cell Development Muscle Organ Development Muscle Structure Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Syntrophin Complex Sarcoglycan Complex Dystroglycan Complex Glucose Import In Response To Insulin Stimulus Cell-substrate Junction Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Vinculin Binding Nitric-oxide Synthase Binding Dystroglycan Binding Vascular Associated Smooth Muscle Cell Development Costamere Neuron Projection Terminus Regulation Of Skeletal Muscle Contraction Filopodium Membrane D-glucose Import Muscle Cell Cellular Homeostasis Peptide Biosynthetic Process Response To Muscle Stretch Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Myosin Binding D-glucose Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Structural Constituent Of Muscle Cardiac Muscle Contraction Myofibril Maintenance Of Blood-brain Barrier Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Development Motile Cilium Assembly Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cardiac Muscle Cell Action Potential Cardiac Cell Development Cardiac Muscle Cell Development Carbohydrate Transmembrane Transport Hexose Transmembrane Transport Carbohydrate Transport Peptide Metabolic Process Skeletal Muscle Tissue Development Lateral Plasma Membrane Regulation Of Sodium Ion Transport Striated Muscle Cell Development	Dystrophin-associated Glycoprotein Complex Sarcolemma Cytoskeleton Muscle Contraction Muscle System Process Syntrophin Complex Structural Molecule Activity Synapse Cytoplasm Actin Binding Costamere Filopodium Cell Body PDZ Domain Binding Mesenchyme Migration Skeletal Muscle Thin Filament Assembly Protein-containing Complex Contractile Ring Dense Core Granule Exocytosis Intermediate Filament Cytoskeleton Z Disc Cell Communication Positive Regulation Of Cell-matrix Adhesion System Process Glial Cell Development Vinculin Binding Ciliary Basal Body Lamellipodium Synaptic Signaling Regulation Of Transport Regulation Of System Process Glutamatergic Synapse Secretory Granule Localization Programmed Necrotic Cell Death Heart Contraction Cell-cell Signaling Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development Presynapse Myosin Binding Signaling Focal Adhesion Plasma Membrane Actomyosin Structure Organization Positive Regulation Of Receptor Internalization Cellular Response To Nutrient Levels Myofibril Assembly Heart Process Organelle Assembly Amyloid-beta Complex
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