SGCZ and SGCB

Number of citations of the paper that reports this interaction (PubMedID 12189167)
0

Data Source:
HPRD (in vitro)

		SGCZ	SGCB
Description		sarcoglycan zeta	sarcoglycan beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Sarcoglycan Complex Membrane Sarcolemma	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma
	Molecular Function		Protein Binding
	Biological Process	Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Muscle Cell Development Heart Contraction Membrane Organization	Muscle Organ Development Response To Glucose Gene Expression Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Muscle Cell Development Cardiac Muscle Cell Development Vascular Associated Smooth Muscle Cell Development
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Depressive symptom improvement ( 30468137) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Endometrial cancer (Non-endometrioid histology) ( 30093612) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Intelligence (MTAG) ( 29326435) Joint damage in rheumatoid arthritis ( 31596875) Methamphetamine dependence ( 23594818) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Platelet aggregation ( 20526338) Retinitis pigmentosa ( 33514863) Severe insulin-deficient type 2 diabetes ( 34737425) Small cell lung carcinoma ( 28604730) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: DMD SGCB SMIM3	22 interacting genes: ADAM33 ADRA1A APOL3 ATP1B4 CLEC7A CMTM5 EHHADH HTR2C LTB4R2 MAL MGST2 NINJ1 PTTG1IP SGCA SGCD SGCG SGCZ SLC52A1 SMIM3 TMEM11 TNF TRIM63
Entrez ID		137868	6443
HPRD ID		12165	02942
Ensembl ID		ENSG00000185053	ENSG00000163069
Uniprot IDs		Q08AT0 Q96LD1	Q16585 Q5U0N0
PDB IDs
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Sarcolemma Muscle Cell Development Muscle Organ Development Muscle Structure Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Syntrophin Complex Sarcoglycan Complex Dystroglycan Complex Glucose Import In Response To Insulin Stimulus Cell-substrate Junction Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Vinculin Binding Nitric-oxide Synthase Binding Dystroglycan Binding Vascular Associated Smooth Muscle Cell Development Costamere Neuron Projection Terminus Regulation Of Skeletal Muscle Contraction Filopodium Membrane D-glucose Import Muscle Cell Cellular Homeostasis Peptide Biosynthetic Process Response To Muscle Stretch Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Myosin Binding D-glucose Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Structural Constituent Of Muscle Cardiac Muscle Contraction Myofibril Maintenance Of Blood-brain Barrier Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Development Motile Cilium Assembly Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cardiac Muscle Cell Action Potential Cardiac Cell Development Cardiac Muscle Cell Development Carbohydrate Transmembrane Transport Hexose Transmembrane Transport Carbohydrate Transport Peptide Metabolic Process Skeletal Muscle Tissue Development Lateral Plasma Membrane Regulation Of Sodium Ion Transport Striated Muscle Cell Development	Sarcoglycan Complex Dystroglycan Complex Membrane Heart Contraction Muscle Contraction Heart Process Sarcolemma Muscle System Process Circulatory System Process Plasma Membrane Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Action Potential Cardiac Muscle Tissue Development Negative Regulation Of Heart Rate Dystrophin-associated Glycoprotein Complex Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Heart Contraction Negative Regulation Of Blood Circulation Muscle Organ Development Negative Regulation Of Myoblast Differentiation Striated Muscle Tissue Development Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Ferroptosis Muscle Structure Development Muscle Tissue Development Negative Regulation Of Bile Acid Secretion Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Metabolic Process Detection Of Yeast Detection Of Molecule Of Fungal Origin Positive Regulation Of Inflammatory Response Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of Action Potential Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure System Process Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
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