TRIM40 and RIGI

Number of citations of the paper that reports this interaction (PubMedID 29117565)
0

Data Source:
BioGRID (enzymatic study)

		TRIM40	RIGI
Description		tripartite motif containing 40	RNA sensor RIG-I
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm IkappaB Kinase Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Membrane Ruffle Membrane Cell Projection Anchoring Junction Ribonucleoprotein Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Nucleic Acid Binding Double-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding GTP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Pattern Recognition Receptor Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Innate Immune Response Protein Neddylation Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MRNA Transcription Detection Of Virus Response To Virus Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Migration Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response
Pathways			ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 27863252 32888494) Neuroticism ( 29255261) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: APP IFIH1 RIGI	21 interacting genes: CCDC50 CYLD DHX16 FILNC1 IRGM MAVS PRKCG RNF122 RNF125 RNF135 SNX5 THAP12 TRIM40 TRIM6 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 USP15 USP3
Entrez ID		135644	23586
HPRD ID		15557	13131
Ensembl ID		ENSG00000204614	ENSG00000107201
Uniprot IDs		A0A0G2JIV5 A0A0G2JMU7 A0A1U9X8U1 Q6P9F5	A0AAQ5BIG4 O95786
PDB IDs			2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG 6KYV 7BAH 7BAI 7JL1 7JL3 7MK1 7TNX 7TNY 7TNZ 7TO0 7TO1 7TO2 8DVR 8DVS 8DVU 8G7T 8G7U 8G7V 8SCZ 8SD0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Type III Interferon Production Detection Of Virus Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Cellular Response To Exogenous DsRNA Cellular Response To DsRNA Positive Regulation Of Interferon-alpha Production Regulation Of Innate Immune Response Pattern Recognition Receptor Activity Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Positive Regulation Of Defense Response Response To DsRNA Single-stranded RNA Binding Positive Regulation Of Cytokine Production MRNA Transcription Regulation Of Interferon-beta Production Positive Regulation Of Response To Cytokine Stimulus Innate Immune Response Double-stranded RNA Binding RNA Helicase Activity Antiviral Innate Immune Response Defense Response To Symbiont Positive Regulation Of Type I Interferon Production Defense Response To Other Organism Regulation Of Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Defense Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Helicase Activity Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Response To Other Organism Pattern Recognition Receptor Signaling Pathway Acetylcholine Receptor Activator Activity Immune Response Positive Regulation Of Gene Expression Lipoprotein Particle Positive Regulation Of Protein Import Innate Immune Response-activating Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury	Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Type I Interferon Production Protein Ubiquitination Protein Polyubiquitination Antiviral Innate Immune Response Protein K48-linked Ubiquitination Protein Metabolic Process Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response NLRP3 Inflammasome Complex Assembly Defense Response To Symbiont Defense Response To Other Organism Macromolecule Metabolic Process Regulation Of Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Proteolysis Ubiquitin Conjugating Enzyme Activity Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Interferon-beta Production Positive Regulation Of Defense Response Negative Regulation Of Type I Interferon Production Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Free Ubiquitin Chain Polymerization Macromolecule Catabolic Process Type I Interferon-mediated Signaling Pathway Response To Other Organism Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production Regulation Of Cytokine Production Positive Regulation Of Peptidyl-threonine Phosphorylation Modification-dependent Protein Catabolic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Zinc Ion Binding Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Protein Autoubiquitination Interferon-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of Immune Response CARD Domain Binding
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