TRIM40

Description		tripartite motif containing 40
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm IkappaB Kinase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Innate Immune Response Protein Neddylation Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways
Drugs
Diseases
GWAS		Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 27863252 32888494) Neuroticism ( 29255261) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: APP IFIH1 RIGI
Entrez ID		135644
HPRD ID		15557
Ensembl ID		ENSG00000204614
Uniprot IDs		A0A0G2JIV5 A0A0G2JMU7 A0A1U9X8U1 Q6P9F5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Type III Interferon Production Detection Of Virus Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Cellular Response To Exogenous DsRNA Cellular Response To DsRNA Positive Regulation Of Interferon-alpha Production Regulation Of Innate Immune Response Pattern Recognition Receptor Activity Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Positive Regulation Of Defense Response Response To DsRNA Single-stranded RNA Binding Positive Regulation Of Cytokine Production MRNA Transcription Regulation Of Interferon-beta Production Positive Regulation Of Response To Cytokine Stimulus Innate Immune Response Double-stranded RNA Binding RNA Helicase Activity Antiviral Innate Immune Response Defense Response To Symbiont Positive Regulation Of Type I Interferon Production Defense Response To Other Organism Regulation Of Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Defense Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Helicase Activity Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Response To Other Organism Pattern Recognition Receptor Signaling Pathway Acetylcholine Receptor Activator Activity Immune Response Positive Regulation Of Gene Expression Lipoprotein Particle Positive Regulation Of Protein Import Innate Immune Response-activating Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury
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