RAD9B and RAD17

Number of citations of the paper that reports this interaction (PubMedID 14611806)
0

Data Source:
HPRD (in vitro, in vivo)

		RAD9B	RAD17
Description		RAD9 checkpoint clamp component B	RAD17 checkpoint clamp loader component
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Checkpoint Clamp Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Rad17 RFC-like Complex Site Of Double-strand Break
	Molecular Function	Protein Binding	Nucleotide Binding Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Negative Regulation Of DNA Replication Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Regulation Of Phosphorylation Protein Localization To Site Of Double-strand Break
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS			Blood urea nitrogen levels ( 31152163)
Interacting Genes		5 interacting genes: HUS1 HUS1B RAD1 RAD17 RAD9A	20 interacting genes: ATM ATR CLSPN CSNK1E CSNK2A1 CSNK2B HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SMG7 SNU13 USP20
Entrez ID		144715	5884
HPRD ID		12221	09124
Ensembl ID		ENSG00000151164	ENSG00000152942
Uniprot IDs		B4DX60 B4DYM6 J3KPN7 Q6WBX8	A0A0G2JP78 O75943
PDB IDs			7Z6H 8GNN
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex DNA Replication Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Damage Checkpoint Signaling Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Phase Transition Meiotic Cell Cycle Checkpoint Signaling Negative Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition DNA Repair Meiotic DNA Integrity Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle DNA Metabolic Process Regulation Of Cell Cycle Process DNA Damage Response Mitotic G2/M Transition Checkpoint Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Double-stranded DNA 3'-5' DNA Exonuclease Activity Site Of Double-strand Break Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Response To Ionizing Radiation Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Radiation Intracellular Signal Transduction Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleotide-excision Repair Response To Radiation Response To Stress Rad17 RFC-like Complex Telomere Maintenance Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Meiotic Recombination Checkpoint Signaling Signal Transduction Nucleolus Double-strand Break Repair Macromolecule Metabolic Process	DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Checkpoint Clamp Complex Negative Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Macromolecule Metabolic Process Mitotic DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Mitotic DNA Integrity Checkpoint Signaling Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Histone H2AXS139 Kinase Activity DNA Strand Elongation Involved In DNA Replication Nucleoplasm Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation DNA Replication Factor C Complex DNA Replication Cellular Response To Radiation Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Double-strand Break Repair DNA-templated DNA Replication Mitotic G2/M Transition Checkpoint Double-strand Break Repair Via Homologous Recombination Nucleus Response To Radiation Recombinational Repair Positive Regulation Of DNA Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
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