PM20D2 and RGS12

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PM20D2	RGS12
Name		peptidase M20 domain containing 2	regulator of G protein signaling 12
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Dendrite Cell Projection Synapse
	Molecular Function	Carboxypeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Dipeptidase Activity Identical Protein Binding Para-aminobenzoyl-glutamate Hydrolase Activity	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity
	Biological Process	Proteolysis Folic Acid Catabolic Process Regulation Of Protein Metabolic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction
Pathways		None	G alpha (i) signalling events G alpha (i) signalling events
GWAS		Serum metabolite levels ( 33031748 )	Adult body size ( 32376654 ) Coronary artery disease ( 29212778 ) Creatinine levels ( 29403010 ) Estimated glomerular filtration rate ( 30604766 31015462 ) Glomerular filtration rate ( 29403010 ) Hepatocyte growth factor levels ( 25998175 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Platelet count ( 29403010 ) Serum albumin levels ( 29403010 ) Total cholesterol levels ( 29403010 33339817 ) Tuberculosis ( 29036319 ) Worry too long after an embarrassing experience ( 29500382 )
Interacting Genes		24 interacting genes: CERT1 CNNM3 DALRD3 DDIT4L DNAJC11 EPDR1 HAPLN2 KEL KRT75 KRTAP26-1 MEOX1 MYOZ3 NAA80 OGT POU6F2 PSMA1 REL RGS12 RP2 RUSC1 SAXO1 SIVA1 TAPBPL TDO2	17 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 PM20D2 YWHAG
Entrez ID		135293	6002
HPRD ID		16473	03943
Ensembl ID		ENSG00000146281	ENSG00000159788
Uniprot IDs		Q8IYS1	O14924
PDB IDs		7YH4 8XZC	2EBZ 2KV8
GO Terms Enriched among Interactors		None	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Guanyl Nucleotide Binding Signal Transduction G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission GTPase Activity Regulation Of Secretion By Cell Negative Regulation Of Catalytic Activity Glutamate Receptor Signaling Pathway Regulation Of Secretion GTP Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Synaptic Transmission, Glutamatergic Membrane GDP Binding Glutamate Receptor Activity Astrocyte Projection Phospholipase C Activity Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Import Into Cytosol Nucleotide Binding G Protein-coupled Glutamate Receptor Signaling Pathway Intracellular Signal Transduction Schwann Cell Development Regulation Of Catalytic Activity Glutamatergic Synapse G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Ciliary Basal Body Cell-cell Signaling Regulation Of Dopamine Secretion Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Signaling Cell Surface Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Signaling