ZNF474 and ATP6V0D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF474	ATP6V0D2
Description		zinc finger protein 474	ATPase H+ transporting V0 subunit d2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Lysosomal Membrane Endosome Early Endosome Endosome Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain Plasma Membrane Proton-transporting V-type ATPase Complex Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process		Monoatomic Ion Transport Vacuolar Transport Vacuolar Acidification Regulation Of Macroautophagy Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Intraocular pressure ( 29617998)	Adverse response to lamotrigine and phenytoin ( 22379998) Neutrophil count ( 32888494)
Interacting Genes		29 interacting genes: ABI2 ATP6V0D2 BANP CABP5 CATSPERT CCDC57 COMMD8 CPNE7 CTNNA3 FRMD8 GPATCH11 GRB2 GYS1 IL16 KCTD7 MCMBP MLH1 NOXA1 PFKFB1 PPL PRKAB2 RSPH14 SEPHS1 TCF19 TEKT4 TRIM23 TSR2 UBASH3A ZIC1	20 interacting genes: ADRM1 AGO3 ARID5A CENPP CRX IKZF3 INCA1 MEOX2 NDUFB8 NICN1 PAX6 PHF12 POMC RBM15B REL RIBC1 RPS3 RUSC1 SEPTIN2 ZNF474
Entrez ID		133923	245972
HPRD ID		13411	16522
Ensembl ID		ENSG00000164185	ENSG00000147614
Uniprot IDs		Q6S9Z5	Q8N8Y2
PDB IDs
Enriched GO Terms of Interacting Partners?			NF-kappaB Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus Nucleoplasm Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II
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