ZNF474 and FRMD8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF474	FRMD8
Description		zinc finger protein 474	FERM domain containing 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Centriolar Satellite
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process		Positive Regulation Of Tumor Necrosis Factor Production Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Intraocular pressure ( 29617998)	Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Serum uric acid levels ( 32271837 32514006) Urate levels ( 31578528)
Interacting Genes		29 interacting genes: ABI2 ATP6V0D2 BANP CABP5 CATSPERT CCDC57 COMMD8 CPNE7 CTNNA3 FRMD8 GPATCH11 GRB2 GYS1 IL16 KCTD7 MCMBP MLH1 NOXA1 PFKFB1 PPL PRKAB2 RSPH14 SEPHS1 TCF19 TEKT4 TRIM23 TSR2 UBASH3A ZIC1	9 interacting genes: APP FATE1 GRAMD2B IKBKG KCNH2 LIME1 PLEKHF2 ZNF446 ZNF474
Entrez ID		133923	83786
HPRD ID		13411	13326
Ensembl ID		ENSG00000164185	ENSG00000126391
Uniprot IDs		Q6S9Z5	A8K6L3 Q9BZ67
PDB IDs
Enriched GO Terms of Interacting Partners?			Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Monoatomic Ion Transport Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Inorganic Ion Homeostasis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Cation Homeostasis Regulation Of Metal Ion Transport Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Heart Rate By Hormone Ubiquitin Protein Ligase Binding T Cell Receptor Signaling Pathway Linear Polyubiquitin Binding Monoatomic Ion Homeostasis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling B Cell Receptor Complex Negative Regulation Of Mitochondrial Calcium Ion Concentration Regulation Of Calcium Ion Transmembrane Transport Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Heart Rate By Chemical Signal Inward Rectifier Potassium Channel Complex Antigen Receptor-mediated Signaling Pathway Regulation Of Spontaneous Synaptic Transmission Homeostatic Process
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