ZNF474 and COMMD8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF474	COMMD8
Description		zinc finger protein 474	COMM domain containing 8
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding NF-kappaB Binding
	Biological Process		Signal Transduction
Pathways			Neddylation
Drugs
Diseases
GWAS		Intraocular pressure ( 29617998)	Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		29 interacting genes: ABI2 ATP6V0D2 BANP CABP5 CATSPERT CCDC57 COMMD8 CPNE7 CTNNA3 FRMD8 GPATCH11 GRB2 GYS1 IL16 KCTD7 MCMBP MLH1 NOXA1 PFKFB1 PPL PRKAB2 RSPH14 SEPHS1 TCF19 TEKT4 TRIM23 TSR2 UBASH3A ZIC1	5 interacting genes: AKR1C1 COMMD1 COXFA4L2 TMX2 ZNF474
Entrez ID		133923	54951
HPRD ID		13411	13086
Ensembl ID		ENSG00000164185	ENSG00000169019
Uniprot IDs		Q6S9Z5	Q9NX08
PDB IDs			8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?			17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Indanol Dehydrogenase Activity Sterol Homeostasis 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity Cellular Response To Jasmonic Acid Stimulus Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Cholesterol Homeostasis Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Ketosteroid Monooxygenase Activity Lipid Homeostasis Regulation Of Plasma Lipoprotein Particle Levels 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity Regulation Of Cholesterol Import Daunorubicin Metabolic Process Carboxylic Acid Binding Androsterone Dehydrogenase [NAD(P)+] Activity Doxorubicin Metabolic Process Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Testosterone Dehydrogenase (NADP+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Bile Acid Binding Disulfide Oxidoreductase Activity Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Negative Regulation Of Sodium Ion Transmembrane Transport Intestinal Cholesterol Absorption Aldose Reductase (NADPH) Activity Plasma Membrane To Endosome Transport Alcohol Dehydrogenase (NADP+) Activity Negative Regulation Of Protein Localization To Cell Surface Intestinal Lipid Absorption Negative Regulation Of Cellular Response To Hypoxia Progesterone Metabolic Process Negative Regulation Of Sodium Ion Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Lipid Binding Low-density Lipoprotein Particle Clearance Retinal Metabolic Process Respiratory Chain Complex IV Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling Bile Acid And Bile Salt Transport Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Regulation Of Cellular Response To Hypoxia
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