ENPP6 and ASPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ENPP6	ASPH
Description		ectonucleotide pyrophosphatase/phosphodiesterase 6	aspartate beta-hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Extracellular Exosome Side Of Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	Protein Binding Phosphoric Diester Hydrolase Activity Glycerophosphodiester Phosphodiesterase Activity Hydrolase Activity Metal Ion Binding Glycerophosphocholine Cholinephosphodiesterase Activity	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity
	Biological Process	Lipid Metabolic Process Lipid Catabolic Process Choline Metabolic Process Glycerophospholipid Catabolic Process	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization
Pathways		Glycerophospholipid catabolism	Stimuli-sensing channels Ion homeostasis Protein hydroxylation
Drugs			Aspartic acid
Diseases
GWAS		Femoral neck bone mineral density ( 30172743) Insomnia ( 29520036) Kawasaki disease ( 33692975) Night sleep phenotypes ( 27126917) Recurrent major depressive disorder ( 34099189) Response to bupropion and depression ( 27622933) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Severe influenza A (H1N1) infection ( 26379185)	Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)
Interacting Genes		1 interacting genes: ASPH	73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16
Entrez ID		133121	444
HPRD ID		16863	08996
Ensembl ID		ENSG00000164303	ENSG00000198363
Uniprot IDs		Q6UWR7	B4DQ07 B7ZM96 G3XAN5 Q12797
PDB IDs			5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9
Enriched GO Terms of Interacting Partners?		Activation Of Store-operated Calcium Channel Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Cortical Endoplasmic Reticulum Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Cation Channel Activity Calcium Channel Complex Positive Regulation Of Ion Transmembrane Transporter Activity Response To ATP Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Transporter Activity Sarcoplasmic Reticulum Membrane Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Face Morphogenesis Structural Constituent Of Muscle Regulation Of Cytosolic Calcium Ion Concentration Electron Transfer Activity Positive Regulation Of Calcium Ion Transmembrane Transport Dioxygenase Activity Sarcoplasmic Reticulum Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Roof Of Mouth Development Regulation Of Cardiac Muscle Contraction Cellular Response To Calcium Ion Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Protein Depolymerization Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Calcium Ion Transport Regulation Of Striated Muscle Contraction Limb Morphogenesis Detection Of Chemical Stimulus Positive Regulation Of Cation Transmembrane Transport Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Monoatomic Ion Transmembrane Transport Transmembrane Transporter Binding Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Intracellular Transport Response To Calcium Ion Regulation Of Intracellular Protein Transport Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Cytosolic Calcium Ion Concentration	Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport
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