ENPP6

Description		ectonucleotide pyrophosphatase/phosphodiesterase 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	Protein Binding Phosphoric Diester Hydrolase Activity Glycerophosphodiester Phosphodiesterase Activity Hydrolase Activity Metal Ion Binding Glycerophosphocholine Cholinephosphodiesterase Activity
	Biological Process	Lipid Metabolic Process Lipid Catabolic Process Choline Metabolic Process Glycerophospholipid Catabolic Process
Pathways		Glycerophospholipid catabolism
Drugs
Diseases
GWAS		Femoral neck bone mineral density ( 30172743) Insomnia ( 29520036) Kawasaki disease ( 33692975) Night sleep phenotypes ( 27126917) Recurrent major depressive disorder ( 34099189) Response to bupropion and depression ( 27622933) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		1 interacting genes: ASPH
Entrez ID		133121
HPRD ID		16863
Ensembl ID		ENSG00000164303
Uniprot IDs		Q6UWR7
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of Store-operated Calcium Channel Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Cortical Endoplasmic Reticulum Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Cation Channel Activity Calcium Channel Complex Positive Regulation Of Ion Transmembrane Transporter Activity Response To ATP Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Transporter Activity Sarcoplasmic Reticulum Membrane Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Face Morphogenesis Structural Constituent Of Muscle Regulation Of Cytosolic Calcium Ion Concentration Electron Transfer Activity Positive Regulation Of Calcium Ion Transmembrane Transport Dioxygenase Activity Sarcoplasmic Reticulum Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Roof Of Mouth Development Regulation Of Cardiac Muscle Contraction Cellular Response To Calcium Ion Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Protein Depolymerization Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Calcium Ion Transport Regulation Of Striated Muscle Contraction Limb Morphogenesis Detection Of Chemical Stimulus Positive Regulation Of Cation Transmembrane Transport Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Monoatomic Ion Transmembrane Transport Transmembrane Transporter Binding Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Intracellular Transport Response To Calcium Ion Regulation Of Intracellular Protein Transport Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Cytosolic Calcium Ion Concentration
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