SYNPR and SLC1A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYNPR	SLC1A1
Description		synaptoporin	solute carrier family 1 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse	Cytoplasm Endosome Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Vesicle Asymmetric Synapse Neuron Projection Neuronal Cell Body Synaptic Cleft Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Membrane Raft Synapse Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Cell Periphery Glial Cell Projection Apical Dendrite Schaffer Collateral - CA1 Synapse Presynapse Perisynaptic Space Distal Dendrite Proximal Dendrite
	Molecular Function	Protein Binding	Monoatomic Anion Channel Activity L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding D-aspartate Transmembrane Transporter Activity
	Biological Process		Behavioral Fear Response Response To Amphetamine Regulation Of Heart Rate Glutathione Metabolic Process Glutathione Biosynthetic Process Superoxide Metabolic Process Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Intracellular Zinc Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Memory Grooming Behavior Locomotory Behavior Response To Xenobiotic Stimulus Positive Regulation Of Heart Rate Gene Expression Retina Layer Formation L-glutamate Transmembrane Transport Cytokine-mediated Signaling Pathway Neurogenesis Adult Behavior Cellular Response To Oxidative Stress Maintenance Of Blood-brain Barrier Response To Decreased Oxygen Levels Dopamine Metabolic Process Cysteine Transport Response To Morphine Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization Blood Vessel Morphogenesis Response To Axon Injury Synapse Organization Neuron Apoptotic Process L-glutamate Import Righting Reflex Retina Development In Camera-type Eye Heart Contraction Long-term Synaptic Potentiation Motor Behavior Transepithelial Transport D-aspartate Transmembrane Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Ammonium Ion Cellular Response To Mercury Ion Cellular Response To Cocaine Zinc Ion Transmembrane Transport Response To Anesthetic Regulation Of Protein Targeting To Membrane Intracellular Glutamate Homeostasis Motor Neuron Apoptotic Process Import Into Cell L-glutamate Import Across Plasma Membrane Neurotransmitter Receptor Transport To Plasma Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport Cysteine Transmembrane Transport Cellular Response To Bisphenol A Conditioned Place Preference
Pathways			Glutamate Neurotransmitter Release Cycle Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC-mediated transport of amino acids
Drugs			Aspartic acid Glutamic acid
Diseases			Dicarboxylic aminoaciduria
GWAS		Autism ( 30675382) Congenital heart disease (inherited effect) ( 28468790) Congenital left-sided heart lesions ( 25138779) Idiopathic downbeat nystagmus ( 32157568) Lean body mass ( 28552196) Major depressive disorder ( 29317602)	Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		11 interacting genes: ARLN CREB3 DOLK FATE1 GALNT15 GPR37L1 KTN1 PLPP6 SLC1A1 SMCO4 TRARG1	16 interacting genes: APP ARL6IP5 C1GALT1 ERGIC3 EWSR1 FAM209A FCER1G FXYD3 LDLRAD1 LMNA PAGE1 PRKCA RNF5 SLC35A1 SYNPR TMEM179B
Entrez ID		132204	6505
HPRD ID		15458	00597
Ensembl ID		ENSG00000163630	ENSG00000106688
Uniprot IDs		Q8TBG9	P43005
PDB IDs			6S3Q 6X2L 6X2Z 6X3E 6X3F 7NSG 8CTC 8CTD 8CUA 8CUD 8CUI 8CUJ 8CV2 8CV3 9D66 9D67 9D68 9D69 9D6A
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum D-aspartate Transmembrane Transporter Activity Positive Regulation Of Deacetylase Activity Dolichol Kinase Activity Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Response To Anesthetic Conditioned Place Preference D-aspartate Import Across Plasma Membrane Cysteine Transmembrane Transport Intracellular Glutamate Homeostasis Vesicle-mediated Transport To The Plasma Membrane Cysteine Transport High-affinity L-glutamate Transmembrane Transporter Activity D-aspartate Transmembrane Transport Cysteine Transmembrane Transporter Activity Response To Ammonium Ion Cellular Response To Ammonium Ion Cellular Response To Mercury Ion Distal Dendrite Glutamate:sodium Symporter Activity Response To Bisphenol A Perisynaptic Space L-aspartate Import Across Plasma Membrane Cellular Response To Bisphenol A Prosaposin Receptor Activity Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation CCR1 Chemokine Receptor Binding Release From Viral Latency Terpenoid Metabolic Process Isoprenoid Metabolic Process Dolichol Phosphate Mannose Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Negative Regulation Of Mitochondrial Calcium Ion Concentration Glucose Import In Response To Insulin Stimulus Lipid Phosphatase Activity Farnesyl Diphosphate Metabolic Process Geranyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Positive Regulation Of Neutrophil Activation
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