SYNPR and DOLK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYNPR	DOLK
Description		synaptoporin	dolichol kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Dolichol Kinase Activity Protein Binding Kinase Activity Transferase Activity
	Biological Process		Protein N-linked Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process
Pathways			Synthesis of dolichyl-phosphate Defective DOLK causes DOLK-CDG
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Autism ( 30675382) Congenital heart disease (inherited effect) ( 28468790) Congenital left-sided heart lesions ( 25138779) Idiopathic downbeat nystagmus ( 32157568) Lean body mass ( 28552196) Major depressive disorder ( 29317602)
Interacting Genes		11 interacting genes: ARLN CREB3 DOLK FATE1 GALNT15 GPR37L1 KTN1 PLPP6 SLC1A1 SMCO4 TRARG1	21 interacting genes: APPBP2 CD79A CHODL CREB3 CREB3L1 EDA FAM209A FNDC9 GALNT8 GJA8 GPX8 KCNA1 KCNA10 KCNA3 KCNA6 SLC7A6 SYNPR TMEM45B TMEM80 UBQLN1 VSIR
Entrez ID		132204	22845
HPRD ID		15458	15525
Ensembl ID		ENSG00000163630	ENSG00000175283
Uniprot IDs		Q8TBG9	A0A0S2Z597 Q9UPQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum D-aspartate Transmembrane Transporter Activity Positive Regulation Of Deacetylase Activity Dolichol Kinase Activity Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Response To Anesthetic Conditioned Place Preference D-aspartate Import Across Plasma Membrane Cysteine Transmembrane Transport Intracellular Glutamate Homeostasis Vesicle-mediated Transport To The Plasma Membrane Cysteine Transport High-affinity L-glutamate Transmembrane Transporter Activity D-aspartate Transmembrane Transport Cysteine Transmembrane Transporter Activity Response To Ammonium Ion Cellular Response To Ammonium Ion Cellular Response To Mercury Ion Distal Dendrite Glutamate:sodium Symporter Activity Response To Bisphenol A Perisynaptic Space L-aspartate Import Across Plasma Membrane Cellular Response To Bisphenol A Prosaposin Receptor Activity Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation CCR1 Chemokine Receptor Binding Release From Viral Latency Terpenoid Metabolic Process Isoprenoid Metabolic Process Dolichol Phosphate Mannose Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Negative Regulation Of Mitochondrial Calcium Ion Concentration Glucose Import In Response To Insulin Stimulus Lipid Phosphatase Activity Farnesyl Diphosphate Metabolic Process Geranyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Positive Regulation Of Neutrophil Activation	Membrane Delayed Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Regulation Of Response To Endoplasmic Reticulum Stress Protein Complex Oligomerization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway L-lysine:L-arginine Antiporter Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Collagen Catabolic Process Regulation Of Collagen Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway
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