KLHL40 and ZNF451

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHL40	ZNF451
Description		kelch like family member 40	zinc finger protein 451
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GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex A Band I Band	Nucleus Nucleoplasm PML Body
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity Sequence-specific DNA Binding Metal Ion Binding SUMO Ligase Activity Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Fiber Development Skeletal Muscle Fiber Differentiation	Protein Sumoylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transcription Initiation By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS
Interacting Genes		13 interacting genes: AHNAK CC2D1B FBXL9P FSD2 LMOD3 REL SAR1A SAXO1 SPMIP4 TASOR2 VDAC1 ZBED1 ZNF451	36 interacting genes: AR CALCOCO2 CBS CDC5L CDCA4 CPTP CREB1 CREBBP FAM118A FXR2 HTT JMJD6 KDM1A KLHL40 LZTR1 MID2 OPLAH PCBD1 PIAS1 PIAS2 PIK3R3 PML PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUMO2 SUMO3 SUV39H1 UBC UBE2I ZBED1 ZNF467
Entrez ID		131377	26036
HPRD ID		11058	10332
Ensembl ID		ENSG00000157119	ENSG00000112200
Uniprot IDs		A8K5H9 Q2TBA0	B4DYS2 Q96JY2 Q9Y4E5
PDB IDs		4ASC	5D2M
Enriched GO Terms of Interacting Partners?		SUMO Ligase Activity	Protein Sumoylation PML Body SUMO Transferase Activity Protein Modification Process Presynaptic Cytosol Postsynaptic Cytosol Enzyme Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Nucleus Protein Tag Activity Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Positive Regulation Of RNA Metabolic Process Transcription Coactivator Activity SUMO Ligase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process S-adenosyl-L-methionine Binding Positive Regulation Of Catabolic Process Ubiquitin-like Protein Ligase Binding Protein Demethylase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process MRF Binding Protein-arginine Omega-N Monomethyltransferase Activity Peptidyl-arginine Methylation Small Protein Activating Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Methyltransferase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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