KLHL40 and SPMIP4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KLHL40	SPMIP4
Description		kelch like family member 40	sperm microtubule inner protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex A Band I Band	Cytoplasm Centrosome Cytoskeleton Cilium Motile Cilium Cell Projection
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Fiber Development Skeletal Muscle Fiber Differentiation
Pathways
Drugs
Diseases
GWAS
Interacting Genes		13 interacting genes: AHNAK CC2D1B FBXL9P FSD2 LMOD3 REL SAR1A SAXO1 SPMIP4 TASOR2 VDAC1 ZBED1 ZNF451	11 interacting genes: APP BCL6 CLCNKA CLIC3 CYSRT1 HSF2BP KCTD9 KLHL40 OIP5 PFDN5 TEKT5
Entrez ID		131377	136895
HPRD ID		11058	12919
Ensembl ID		ENSG00000157119	ENSG00000153790
Uniprot IDs		A8K5H9 Q2TBA0	Q8N865
PDB IDs		4ASC
Enriched GO Terms of Interacting Partners?		SUMO Ligase Activity	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Myeloid Cell Development Regulation Of Protein Import Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Regulation Of Amyloid Fibril Formation Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Mast Cell Cytokine Production Isotype Switching To IgE Isotypes Negative Regulation Of Plasma Cell Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Chloride Channel Complex Chloride Transmembrane Transport Chloride Channel Activity RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly Protein-disulfide Reductase (glutathione) Activity Pericentric Heterochromatin Organization CENP-A Recruiting Complex
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