KLHL40 and CC2D1B

Number of citations of the paper that reports this interaction (PubMedID 24960163)
62

Data Source:
BioGRID (two hybrid)

		KLHL40	CC2D1B
Description		kelch like family member 40	coiled-coil and C2 domain containing 1B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex A Band I Band	Nucleus Nuclear Envelope Nucleoplasm Cytosol Endosome Membrane
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Fiber Development Skeletal Muscle Fiber Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways			Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS
Interacting Genes		13 interacting genes: AHNAK CC2D1B FBXL9P FSD2 LMOD3 REL SAR1A SAXO1 SPMIP4 TASOR2 VDAC1 ZBED1 ZNF451	5 interacting genes: KLHL40 LINC00839 MDFI RNF10 SPP1
Entrez ID		131377	200014
HPRD ID		11058	12393
Ensembl ID		ENSG00000157119	ENSG00000154222
Uniprot IDs		A8K5H9 Q2TBA0	Q5T0F9
PDB IDs		4ASC
Enriched GO Terms of Interacting Partners?		SUMO Ligase Activity	Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Negative Regulation Of Nervous System Development Negative Regulation Of Neurogenesis Regulation Of Estradiol Secretion Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Positive Regulation Of Bone Resorption Response To Macrophage Colony-stimulating Factor Hormone Catabolic Process Androgen Catabolic Process Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Cellular Response To Testosterone Stimulus Regulation Of Neurogenesis Negative Regulation Of Neuron Projection Regeneration Negative Regulation Of Cell Development Response To 2,3,7,8-tetrachlorodibenzodioxine Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Skeletal Muscle Fiber Differentiation A Band
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