ACE and AGTR2

Number of citations of the paper that reports this interaction (PubMedID 11459796)
0

Data Source:
HPRD (in vivo)

		ACE	AGTR2
Description		angiotensin I converting enzyme	angiotensin II receptor type 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Actin Binding Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Metalloendopeptidase Activity Protein Binding Calmodulin Binding Peptidase Activity Metallopeptidase Activity Exopeptidase Activity Tripeptidyl-peptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Hydrolase Activity Chloride Ion Binding Mitogen-activated Protein Kinase Kinase Binding Bradykinin Receptor Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Metallodipeptidase Activity	G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Receptor Antagonist Activity
	Biological Process	Kidney Development Blood Vessel Remodeling Angiotensin Maturation Regulation Of Renal Output By Angiotensin Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Neutrophil Mediated Immunity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Systemic Arterial Blood Pressure Proteolysis Spermatogenesis Regulation Of Blood Pressure Male Gonad Development Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Substance P Catabolic Process Bradykinin Catabolic Process Regulation Of Smooth Muscle Cell Migration Regulation Of Vasoconstriction Mononuclear Cell Proliferation Angiotensin-activated Signaling Pathway Vasodilation Hormone Metabolic Process Hormone Catabolic Process Peptide Catabolic Process Regulation Of Synaptic Plasticity Amyloid-beta Metabolic Process Arachidonate Secretion Heart Contraction Regulation Of Angiotensin Metabolic Process Hematopoietic Stem Cell Differentiation Cell Proliferation In Bone Marrow Regulation Of Heart Rate By Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Gap Junction Assembly	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Brain Renin-angiotensin System Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Brain Development Regulation Of Blood Pressure Negative Regulation Of Heart Rate Negative Regulation Of Cell Growth Regulation Of Metanephros Size Exploration Behavior Nitric Oxide-cGMP-mediated Signaling Angiotensin-activated Signaling Pathway Vasodilation Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of DNA-templated Transcription Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Blood Vessel Diameter Maintenance Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Metabolism of Angiotensinogen to Angiotensins	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Omapatrilat Rescinnamine Captopril Cilazapril Spirapril Epicaptopril N-acetyl-alpha-D-glucosamine Temocapril Enalaprilat Zofenopril Cilazaprilat	Tasosartan CYT006-AngQb Olodanrigan
Diseases		Allograft rejection Renal tubular dysgenesis	Non-syndromic X-linked mental retardation
GWAS		Adventurousness ( 30643258) Alzheimer's disease (late onset) ( 24162737 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Angiotensin-converting enzyme activity ( 20066004) Blood protein levels ( 30072576) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diastolic blood pressure ( 27841878 28135244 28739976) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hodgkin's lymphoma ( 34216518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 21886157) Metabolite levels ( 23281178) Serum metabolite levels ( 24625756 33031748 23093944) Systolic blood pressure ( 30578418 27841878) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 2 diabetes ( 30297969)	Cystic fibrosis severity ( 21602797) Gestational age at birth (maternal effect) ( 28877031) Lung disease severity in cystic fibrosis ( 26417704) Offspring birth weight ( 31043758) Preterm birth (maternal effect) ( 28877031) Type 2 diabetes ( 29358691 30130595)
Interacting Genes		4 interacting genes: AGTR2 BDKRB2 COMT CSNK2A1	13 interacting genes: ACE ACE2 AGT AGTRAP ARRB2 ERBB3 ERBIN GNAI2 GNAI3 MTUS1 PIK3CB SNTA1 ZBTB16
Entrez ID		1636	186
HPRD ID		00108	02071
Ensembl ID		ENSG00000159640	ENSG00000180772
Uniprot IDs		B4DKH4 P12821	P50052
PDB IDs		1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK 4BZR 4BZS 4C2N 4C2O 4C2P 4C2Q 4C2R 4CA5 4CA6 4UFA 4UFB 5AM8 5AM9 5AMA 5AMB 5AMC 6EN5 6EN6 6F9R 6F9T 6F9U 6F9V 6H5W 6H5X 6QS1 6TT1 6TT3 6TT4 6ZPQ 6ZPT 6ZPU 7Q24 7Q25 7Q26 7Q27 7Q28 7Q29 7Q3Y 7Q49 7Q4C 7Q4D 7Q4E 7Z6Z 7Z70 8QFX 8QHL 9GBL 9GBM 9GBN 9GBO 9GBP 9GBQ 9GBR 9GBS	5UNF 5UNG 5UNH 5XJM 6JOD 7C6A 7JNI
Enriched GO Terms of Interacting Partners?		Vasodilation Regulation Of Apoptotic Signaling Pathway Exploration Behavior Negative Regulation Of Signal Transduction By P53 Class Mediator Kidney Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Blood Vessel Diameter Maintenance Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Blood Pressure Regulation Of Tube Size Angiotensin Type II Receptor Activity Regulation Of Metanephros Size Brain Renin-angiotensin System Positive Regulation Of Metanephric Glomerulus Development Bradykinin Receptor Activity Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Cellular Response To Phosphate Starvation Norepinephrine Secretion Habituation Mastication Catechol O-methyltransferase Activity Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Glomerulus Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Type 1 Angiotensin Receptor Binding Cerebellar Cortex Morphogenesis Positive Regulation Of Aggrephagy Regulation Of Kidney Size Regulation Of Blood Volume By Renin-angiotensin Dopamine Secretion Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Blood Circulation Vascular Process In Circulatory System Regulation Of Biological Quality Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure O-methyltransferase Activity Renal Protein Absorption Norepinephrine Transport Nonassociative Learning Response To Dopamine	Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Gap Junction Assembly Angiotensin-activated Signaling Pathway Type 2 Angiotensin Receptor Binding Peptidyl-dipeptidase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Renal Output By Angiotensin Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Pressure Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Vasoconstriction Positive Regulation Of Reactive Oxygen Species Metabolic Process Plasma Membrane G Protein-coupled Receptor Binding Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signal Transduction Regulation Of Blood Circulation Angiotensin Maturation Regulation Of System Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Guanyl Nucleotide Binding Renal System Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation G-protein Beta/gamma-subunit Complex Binding Regulation Of Reactive Oxygen Species Metabolic Process Metallocarboxypeptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Regulation Of Superoxide Metabolic Process Negative Regulation Of Catalytic Activity Carboxypeptidase Activity Negative Regulation Of MAPK Cascade Kidney Development Regulation Of Intracellular Signal Transduction Sodium Channel Regulator Activity
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