ACE and AGTR2

Number of citations of the paper that reports this interaction (PMID 11459796)
3

Data Source:
HPRD (in vivo)

		ACE	AGTR2
Gene Name		angiotensin I converting enzyme	angiotensin II receptor, type 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Endopeptidase Activity Carboxypeptidase Activity Protein Binding Drug Binding Metallopeptidase Activity Exopeptidase Activity Tripeptidyl-peptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Chloride Ion Binding Mitogen-activated Protein Kinase Kinase Binding Bradykinin Receptor Binding Mitogen-activated Protein Kinase Binding	Angiotensin Type II Receptor Activity Protein Binding Transcription Factor Binding Peptide Hormone Binding Receptor Antagonist Activity
	Biological Process	Kidney Development Blood Vessel Remodeling Angiotensin Maturation Angiotensin Catabolic Process In Blood Regulation Of Renal Output By Angiotensin Neutrophil Mediated Immunity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Spermatogenesis Regulation Of Blood Pressure Regulation Of Smooth Muscle Cell Migration Regulation Of Vasoconstriction Mononuclear Cell Proliferation Regulation Of Vasodilation Hormone Catabolic Process Peptide Catabolic Process Cellular Protein Metabolic Process Beta-amyloid Metabolic Process Arachidonic Acid Secretion Heart Contraction Regulation Of Angiotensin Metabolic Process Hematopoietic Stem Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Cell Proliferation In Bone Marrow Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Gap Junction Assembly Positive Regulation Of Peptidyl-cysteine S-nitrosylation	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure Brain Renin-angiotensin System Cellular Sodium Ion Homeostasis Inflammatory Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Nitric Oxide Mediated Signal Transduction Brain Development Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Negative Regulation Of Heart Rate Negative Regulation Of Norepinephrine Secretion Cerebellar Cortex Development Negative Regulation Of Cell Growth Negative Regulation Of Icosanoid Secretion Positive Regulation Of Phosphoprotein Phosphatase Activity Intracellular Signal Transduction Regulation Of Metanephros Size Exploration Behavior Positive Regulation Of Renal Sodium Excretion Aldosterone Secretion Angiotensin-activated Signaling Pathway Dopamine Biosynthetic Process Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Dexamethasone Stimulus Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Extracellular Negative Regulation Of Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Rescinnamine Captopril Cilazapril Spirapril 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Temocapril
Diseases
GWAS		Angiotensin-converting enzyme activity ( 20066004) Metabolic traits ( 21886157) Metabolite levels ( 23281178)	Cystic fibrosis severity ( 21602797)
Protein-Protein Interactions		4 interactors: AGTR2 BDKRB2 COMT CSNK2A1	11 interactors: ACE AGT AGTRAP ERBB2IP ERBB3 GNAI2 GNAI3 MTUS1 PIK3CB SNTA1 ZBTB16
Entrez ID		1636	186
HPRD ID		00108	02071
Ensembl ID		ENSG00000159640	ENSG00000180772
Uniprot IDs		B4DKH4 P12821	P50052
PDB IDs		1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK
Enriched GO Terms of Interacting Partners?		Regulation Of Renal Sodium Excretion Regulation Of Excretion Dopamine Metabolic Process Vasodilation Catecholamine Metabolic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Phenol-containing Compound Metabolic Process Positive Regulation Of Homocysteine Metabolic Process Cellular Response To Phosphate Starvation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Aldosterone Secretion Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Ion Homeostasis Regulation Of Homocysteine Metabolic Process Regulation Of Metanephros Size Negative Regulation Of Secretion Negative Regulation Of Dopamine Metabolic Process G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Icosanoid Secretion Regulation Of Kidney Size Renin-angiotensin Regulation Of Aldosterone Production Muscle System Process Regulation Of Hormone Levels Positive Regulation Of Metanephric Glomerulus Development Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Apoptotic Process Negative Regulation Of Renal Sodium Excretion Dopamine Catabolic Process Regulation Of Cell Proliferation Lipid Transport Blood Circulation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Catecholamine Catabolic Process Regulation Of Cell Death Lipid Localization Angiotensin-activated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Regulation Of Cell Growth Brain Renin-angiotensin System Regulation Of Response To Osmotic Stress Positive Regulation Of Glomerulus Development Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Heart Rate Cellular Metal Ion Homeostasis Inflammatory Response	Regulation Of Renal Output By Angiotensin Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Vasoconstriction Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Angiotensin Maturation Regulation Of Protein Kinase Activity Regulation Of Angiotensin Metabolic Process Regulation Of Blood Volume By Renin-angiotensin Regulation Of Kinase Activity Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Phosphorylation Cell Division Positive Regulation Of Protein Modification Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Adenylate Cyclase Activity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Lyase Activity Phosphatidylinositol 3-kinase Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Blood Pressure Regulation Of Protein Phosphorylation Negative Regulation Of CAMP Biosynthetic Process Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Wound Healing Peptide Hormone Processing Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Nucleotide Metabolic Process Regulation Of Immune System Process Regulation Of Phosphorylation Cell Activation Regulation Of Protein Metabolic Process Blood Vessel Remodeling Regulation Of Cellular Component Movement Regulation Of Vasodilation
Tagcloud ?		aminoguanidine attendant augmentation blue blunted cardioprotection cgmp cilazaprilat ck creatine cyclase fashion guanylate hypoxia indomethacin methylene monoacetate monomethyl myocardium myocyte myocytes nmma nonmyocytes paracrine preservation preserved reoxygenated reoxygenation staurosporine	ace acquired acquisition adjuvant agtr1 angiotensin blockers captopril continuously converting endocrine expressions innate losartan mcf mtt mumol phenotype prevention preventive problem qrt ras renin resistant reversion tam tamoxifen viability
Tagcloud (Difference) ?		aminoguanidine attendant augmentation blue blunted cardioprotection cgmp cilazaprilat ck creatine cyclase fashion guanylate hypoxia indomethacin methylene monoacetate monomethyl myocardium myocyte myocytes nmma nonmyocytes paracrine preservation preserved reoxygenated reoxygenation staurosporine	acquired acquisition adjuvant agtr1 angiotensin blockers captopril continuously converting endocrine expressions innate losartan mcf mtt mumol phenotype prevention preventive problem qrt ras renin resistant reversion tam tamoxifen viability
Tagcloud (Intersection) ?		ace