ACE

Gene Name		angiotensin I converting enzyme
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Endopeptidase Activity Carboxypeptidase Activity Protein Binding Drug Binding Metallopeptidase Activity Exopeptidase Activity Tripeptidyl-peptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Chloride Ion Binding Mitogen-activated Protein Kinase Kinase Binding Bradykinin Receptor Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Kidney Development Blood Vessel Remodeling Angiotensin Maturation Angiotensin Catabolic Process In Blood Regulation Of Renal Output By Angiotensin Neutrophil Mediated Immunity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Spermatogenesis Regulation Of Blood Pressure Regulation Of Smooth Muscle Cell Migration Regulation Of Vasoconstriction Mononuclear Cell Proliferation Regulation Of Vasodilation Hormone Catabolic Process Peptide Catabolic Process Cellular Protein Metabolic Process Beta-amyloid Metabolic Process Arachidonic Acid Secretion Heart Contraction Regulation Of Angiotensin Metabolic Process Hematopoietic Stem Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Cell Proliferation In Bone Marrow Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Gap Junction Assembly Positive Regulation Of Peptidyl-cysteine S-nitrosylation
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs		Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Rescinnamine Captopril Cilazapril Spirapril 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Temocapril
Diseases
GWAS		Angiotensin-converting enzyme activity ( 20066004) Metabolic traits ( 21886157) Metabolite levels ( 23281178)
Protein-protein Interactions		4 interactors: AGTR2 BDKRB2 COMT CSNK2A1
Entrez ID		1636
HPRD ID		00108
Ensembl ID		ENSG00000159640
Uniprot IDs		B4DKH4 P12821
PDB IDs		1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK
Enriched GO Terms of Interacting Partners?		Regulation Of Renal Sodium Excretion Regulation Of Excretion Dopamine Metabolic Process Vasodilation Catecholamine Metabolic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Phenol-containing Compound Metabolic Process Positive Regulation Of Homocysteine Metabolic Process Cellular Response To Phosphate Starvation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Aldosterone Secretion Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Ion Homeostasis Regulation Of Homocysteine Metabolic Process Regulation Of Metanephros Size Negative Regulation Of Secretion Negative Regulation Of Dopamine Metabolic Process G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Icosanoid Secretion Regulation Of Kidney Size Renin-angiotensin Regulation Of Aldosterone Production Muscle System Process Regulation Of Hormone Levels Positive Regulation Of Metanephric Glomerulus Development Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Apoptotic Process Negative Regulation Of Renal Sodium Excretion Dopamine Catabolic Process Regulation Of Cell Proliferation Lipid Transport Blood Circulation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Catecholamine Catabolic Process Regulation Of Cell Death Lipid Localization Angiotensin-activated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Regulation Of Cell Growth Brain Renin-angiotensin System Regulation Of Response To Osmotic Stress Positive Regulation Of Glomerulus Development Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Heart Rate Cellular Metal Ion Homeostasis Inflammatory Response
Tagcloud ?		aminoguanidine attendant augmentation blue blunted cardioprotection cgmp cilazaprilat ck creatine cyclase fashion guanylate hypoxia indomethacin methylene monoacetate monomethyl myocardium myocyte myocytes nmma nonmyocytes paracrine preservation preserved reoxygenated reoxygenation staurosporine