ACE and BDKRB2

Number of citations of the paper that reports this interaction (PMID 10748135)
13

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vivo)

		ACE	BDKRB2
Gene Name		angiotensin I converting enzyme	bradykinin receptor B2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Actin Binding Endopeptidase Activity Carboxypeptidase Activity Protein Binding Drug Binding Metallopeptidase Activity Exopeptidase Activity Tripeptidyl-peptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Chloride Ion Binding Mitogen-activated Protein Kinase Kinase Binding Bradykinin Receptor Binding Mitogen-activated Protein Kinase Binding	Protease Binding Phosphatidylinositol Phospholipase C Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Kidney Development Blood Vessel Remodeling Angiotensin Maturation Angiotensin Catabolic Process In Blood Regulation Of Renal Output By Angiotensin Neutrophil Mediated Immunity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Spermatogenesis Regulation Of Blood Pressure Regulation Of Smooth Muscle Cell Migration Regulation Of Vasoconstriction Mononuclear Cell Proliferation Regulation Of Vasodilation Hormone Catabolic Process Peptide Catabolic Process Cellular Protein Metabolic Process Beta-amyloid Metabolic Process Arachidonic Acid Secretion Heart Contraction Regulation Of Angiotensin Metabolic Process Hematopoietic Stem Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Cell Proliferation In Bone Marrow Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Gap Junction Assembly Positive Regulation Of Peptidyl-cysteine S-nitrosylation	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Metabolic Process Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Rescinnamine Captopril Cilazapril Spirapril 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Temocapril
Diseases
GWAS		Angiotensin-converting enzyme activity ( 20066004) Metabolic traits ( 21886157) Metabolite levels ( 23281178)
Protein-Protein Interactions		4 interactors: AGTR2 BDKRB2 COMT CSNK2A1	12 interactors: ACE ADRBK1 ADRBK2 AGTR1 GNA11 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11
Entrez ID		1636	624
HPRD ID		00108	00213
Ensembl ID		ENSG00000159640	ENSG00000168398
Uniprot IDs		B4DKH4 P12821	P30411
PDB IDs		1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK
Enriched GO Terms of Interacting Partners?		Regulation Of Renal Sodium Excretion Regulation Of Excretion Dopamine Metabolic Process Vasodilation Catecholamine Metabolic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Phenol-containing Compound Metabolic Process Positive Regulation Of Homocysteine Metabolic Process Cellular Response To Phosphate Starvation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Aldosterone Secretion Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Ion Homeostasis Regulation Of Homocysteine Metabolic Process Regulation Of Metanephros Size Negative Regulation Of Secretion Negative Regulation Of Dopamine Metabolic Process G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Icosanoid Secretion Regulation Of Kidney Size Renin-angiotensin Regulation Of Aldosterone Production Muscle System Process Regulation Of Hormone Levels Positive Regulation Of Metanephric Glomerulus Development Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Apoptotic Process Negative Regulation Of Renal Sodium Excretion Dopamine Catabolic Process Regulation Of Cell Proliferation Lipid Transport Blood Circulation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Catecholamine Catabolic Process Regulation Of Cell Death Lipid Localization Angiotensin-activated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Regulation Of Cell Growth Brain Renin-angiotensin System Regulation Of Response To Osmotic Stress Positive Regulation Of Glomerulus Development Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Heart Rate Cellular Metal Ion Homeostasis Inflammatory Response	Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Vasodilation Negative Regulation Of Signal Transduction Blood Circulation Regulation Of The Force Of Heart Contraction Signal Transduction Regulation Of Signal Transduction Receptor Internalization Blood Coagulation Signaling Hemostasis Regulation Of Blood Pressure Regulation Of Signaling Cell Communication Positive Regulation Of Catalytic Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Wound Healing Arginine Catabolic Process Cellular Response To Stimulus Tachykinin Receptor Signaling Pathway Receptor Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Guanylate Cyclase Activity Response To Wounding Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Biosynthetic Process Regulation Of Blood Volume By Renin-angiotensin Protein Phosphorylation Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cell Surface Receptor Signaling Pathway Negative Regulation Of Platelet Activation Cellular Protein Metabolic Process Nitric Oxide Mediated Signal Transduction Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Protein Modification Process Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of CGMP Metabolic Process Arginine Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of MRNA Catabolic Process Regulation Of Catalytic Activity Negative Regulation Of Potassium Ion Transport Regulation Of CGMP Biosynthetic Process
Tagcloud ?		aminoguanidine attendant augmentation blue blunted cardioprotection cgmp cilazaprilat ck creatine cyclase fashion guanylate hypoxia indomethacin methylene monoacetate monomethyl myocardium myocyte myocytes nmma nonmyocytes paracrine preservation preserved reoxygenated reoxygenation staurosporine	arg10 arg9 arrangement b1 bk box consensus des entirely etc exon exons extension exudation flanking hyperalgesia hyperemia intron introns kallidin kinin kininase lys noncoding primer sequenced situated tata
Tagcloud (Difference) ?		aminoguanidine attendant augmentation blue blunted cardioprotection cgmp cilazaprilat ck creatine cyclase fashion guanylate hypoxia indomethacin methylene monoacetate monomethyl myocardium myocyte myocytes nmma nonmyocytes paracrine preservation preserved reoxygenated reoxygenation staurosporine	arg10 arg9 arrangement b1 bk box consensus des entirely etc exon exons extension exudation flanking hyperalgesia hyperemia intron introns kallidin kinin kininase lys noncoding primer sequenced situated tata
Tagcloud (Intersection) ?