ACE and BDKRB2

Number of citations of the paper that reports this interaction (PubMedID 17077303)
51

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vivo)

		ACE	BDKRB2
Description		angiotensin I converting enzyme	bradykinin receptor B2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome	Endosome Plasma Membrane Membrane
	Molecular Function	Actin Binding Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Metalloendopeptidase Activity Protein Binding Calmodulin Binding Peptidase Activity Metallopeptidase Activity Exopeptidase Activity Tripeptidyl-peptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Hydrolase Activity Chloride Ion Binding Mitogen-activated Protein Kinase Kinase Binding Bradykinin Receptor Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Metallodipeptidase Activity	Protease Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Kidney Development Blood Vessel Remodeling Angiotensin Maturation Regulation Of Renal Output By Angiotensin Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Neutrophil Mediated Immunity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Systemic Arterial Blood Pressure Proteolysis Spermatogenesis Regulation Of Blood Pressure Male Gonad Development Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Substance P Catabolic Process Bradykinin Catabolic Process Regulation Of Smooth Muscle Cell Migration Regulation Of Vasoconstriction Mononuclear Cell Proliferation Angiotensin-activated Signaling Pathway Vasodilation Hormone Metabolic Process Hormone Catabolic Process Peptide Catabolic Process Regulation Of Synaptic Plasticity Amyloid-beta Metabolic Process Arachidonate Secretion Heart Contraction Regulation Of Angiotensin Metabolic Process Hematopoietic Stem Cell Differentiation Cell Proliferation In Bone Marrow Regulation Of Heart Rate By Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Gap Junction Assembly	System Process Smooth Muscle Contraction Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonate Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways		Metabolism of Angiotensinogen to Angiotensins	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Omapatrilat Rescinnamine Captopril Cilazapril Spirapril Epicaptopril N-acetyl-alpha-D-glucosamine Temocapril Enalaprilat Zofenopril Cilazaprilat	Anatibant Icatibant Labradimil
Diseases		Allograft rejection Renal tubular dysgenesis
GWAS		Adventurousness ( 30643258) Alzheimer's disease (late onset) ( 24162737 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Angiotensin-converting enzyme activity ( 20066004) Blood protein levels ( 30072576) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diastolic blood pressure ( 27841878 28135244 28739976) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hodgkin's lymphoma ( 34216518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 21886157) Metabolite levels ( 23281178) Serum metabolite levels ( 24625756 33031748 23093944) Systolic blood pressure ( 30578418 27841878) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 2 diabetes ( 30297969)	Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		4 interacting genes: AGTR2 BDKRB2 COMT CSNK2A1	33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4
Entrez ID		1636	624
HPRD ID		00108	00213
Ensembl ID		ENSG00000159640	ENSG00000168398
Uniprot IDs		B4DKH4 P12821	P30411
PDB IDs		1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK 4BZR 4BZS 4C2N 4C2O 4C2P 4C2Q 4C2R 4CA5 4CA6 4UFA 4UFB 5AM8 5AM9 5AMA 5AMB 5AMC 6EN5 6EN6 6F9R 6F9T 6F9U 6F9V 6H5W 6H5X 6QS1 6TT1 6TT3 6TT4 6ZPQ 6ZPT 6ZPU 7Q24 7Q25 7Q26 7Q27 7Q28 7Q29 7Q3Y 7Q49 7Q4C 7Q4D 7Q4E 7Z6Z 7Z70 8QFX 8QHL 9GBL 9GBM 9GBN 9GBO 9GBP 9GBQ 9GBR 9GBS	7F2O 7F6H 7F6I
Enriched GO Terms of Interacting Partners?		Vasodilation Regulation Of Apoptotic Signaling Pathway Exploration Behavior Negative Regulation Of Signal Transduction By P53 Class Mediator Kidney Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Blood Vessel Diameter Maintenance Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Blood Pressure Regulation Of Tube Size Angiotensin Type II Receptor Activity Regulation Of Metanephros Size Brain Renin-angiotensin System Positive Regulation Of Metanephric Glomerulus Development Bradykinin Receptor Activity Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Cellular Response To Phosphate Starvation Norepinephrine Secretion Habituation Mastication Catechol O-methyltransferase Activity Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Glomerulus Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Type 1 Angiotensin Receptor Binding Cerebellar Cortex Morphogenesis Positive Regulation Of Aggrephagy Regulation Of Kidney Size Regulation Of Blood Volume By Renin-angiotensin Dopamine Secretion Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Blood Circulation Vascular Process In Circulatory System Regulation Of Biological Quality Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure O-methyltransferase Activity Renal Protein Absorption Norepinephrine Transport Nonassociative Learning Response To Dopamine	G Protein-coupled Receptor Kinase Activity Beta-adrenergic Receptor Kinase Activity Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Binding Vasodilation Protein Serine/threonine Kinase Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of The Force Of Heart Contraction Regulation Of Blood Pressure Receptor-mediated Endocytosis Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Cadmium Ion Binding Protein Kinase Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Adaptation Of Signaling Pathway L-arginine Catabolic Process Regulation Of Systemic Arterial Blood Pressure Tachykinin Receptor Signaling Pathway Arginine Binding Regulation Of Blood Circulation Kinase Activity Plasma Membrane Membrane Vascular Process In Circulatory System Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin FMN Binding Circulatory System Process G Protein-coupled Receptor Binding Regulation Of Heart Contraction G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Biological Quality Regulation Of System Process Arginine Metabolic Process Negative Regulation Of Platelet Activation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Mediated Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Metalloendopeptidase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling
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