FLACC1 and ATP6V1H

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FLACC1	ATP6V1H
Description		flagellum associated containing coiled-coil domains 1	ATPase H+ transporting V1 subunit H
Image		No pdb structure
GO Annotations	Cellular Component	Outer Dense Fiber Cytoplasm Cilium Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Protein Binding	Protein Binding ATP Hydrolysis Activity Enzyme Regulator Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process		Monoatomic Ion Transport Endocytosis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Nef Mediated CD4 Down-regulation Nef Mediated CD8 Down-regulation Insulin receptor recycling Transferrin endocytosis and recycling Blockage of phagosome acidification Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs			Tiludronic acid
Diseases
GWAS			Bipolar disorder with mood-incongruent psychosis ( 23092984) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		22 interacting genes: ATP6V1H BLK CRK DISC1 DVL3 FAM90A1 INO80B LGALS14 LONRF1 PRPF31 SPG21 SSX2 SSX2B SSX4 SSX4B STK16 SULT2B1 TCL1A TEPSIN TRIM41 TXNDC5 YES1	10 interacting genes: ATP6V1E1 CDKN2B ETHE1 FLACC1 PPP1R12C SNPH SOX9 SPATA2 TANK TRIM14
Entrez ID		130540	51606
HPRD ID		12444	10591
Ensembl ID		ENSG00000155749	ENSG00000047249
Uniprot IDs		A8K8B8 Q96Q35	B3KUZ7 Q9UI12
PDB IDs			6WM2 6WM3 6WM4 7FDA 7FDB 7FDC 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta	Proton-transporting Two-sector ATPase Complex, Catalytic Domain Response To Interleukin-1 Neural Crest Cell Fate Specification Male Germ-line Sex Determination Cellular Response To Interleukin-1 Negative Regulation Of Beta-catenin-TCF Complex Assembly Bronchus Cartilage Development Ureter Urothelium Development Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Regulation Of Cell Proliferation Involved In Tissue Homeostasis Ureter Smooth Muscle Cell Differentiation Lung Smooth Muscle Development Intrahepatic Bile Duct Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Ubiquitin-specific Protease Activity Sulfur Dioxygenase Activity Cytoplasm Proton-transporting Two-sector ATPase Complex Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Cell-matrix Adhesion Negative Regulation Of Photoreceptor Cell Differentiation Metanephric Tubule Formation Stem Cell Fate Specification Renal Vesicle Induction Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Chondrocyte Hypertrophy Cell Proliferation Involved In Heart Morphogenesis Trachea Cartilage Development Response To Heparin Prostate Gland Morphogenesis Cellular Response To Heparin Regulation Of Branching Involved In Lung Morphogenesis Endochondral Bone Morphogenesis Anterior Head Development Primary Sex Determination Harderian Gland Development Astrocyte Fate Commitment Common Bile Duct Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Growth Plate Cartilage Chondrocyte Growth Lacrimal Gland Development Protein Linear Deubiquitination Protein Deubiquitination Protein Modification By Small Protein Removal Positive Regulation Of Protein Deubiquitination Hydrogen Sulfide Metabolic Process Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Ureter Development
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