PLEKHH2 and LPXN

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		PLEKHH2	LPXN
Description		pleckstrin homology, MyTH4 and FERM domain containing H2	leupaxin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Body Lamellipodium Cortical Actin Cytoskeleton Cell Projection Cell Periphery	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Actin Binding Protein Binding	Transcription Coregulator Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Actin Filament Depolymerization	Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly
Pathways
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: LPXN PXN	33 interacting genes: AGXT AQP1 GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 LMO3 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RNF214 RUNX1T1 SFI1 TGFB1 TNS2 TXLNB VCL ZNF175 ZNF426
Entrez ID		130271	9404
HPRD ID		15149	05651
Ensembl ID		ENSG00000152527	ENSG00000110031
Uniprot IDs		Q8IVE3	B7Z5P7 O60711
PDB IDs			1X3H 4XEF 4XEK 4XEV
Enriched GO Terms of Interacting Partners?		Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Transforming Growth Factor Beta Receptor Signaling Pathway Cell-substrate Adhesion Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Anchoring Junction Focal Adhesion Signal Complex Assembly Vinculin Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Neuropilin Binding Cell Adhesion Cell Migration Growth Hormone Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Cell Motility Microtubule Associated Complex Podosome Protein-containing Complex Assembly Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Stress Fiber Assembly Protein-containing Complex Organization Positive Regulation Of Actin Filament Bundle Assembly Stress Fiber Protein Phosphatase Binding Regulation Of Stress Fiber Assembly Beta-catenin Binding Cellular Response To Reactive Oxygen Species Cell Surface Receptor Signaling Pathway Transcription Coregulator Activity	Response To Dexamethasone Focal Adhesion Positive Regulation Of Fibroblast Migration Developmental Growth Developmental Growth Involved In Morphogenesis Anchoring Junction Cellular Response To Dexamethasone Stimulus Cellular Response To Lipid Cellular Response To Oxygen-containing Compound Multicellular Organismal-level Homeostasis Positive Regulation Of Mononuclear Cell Migration Regulation Of Fibroblast Migration Response To Fluid Shear Stress Developmental Cell Growth Response To Lipid Signal Complex Assembly Regulation Of Cell-matrix Adhesion Response To Glucocorticoid Regulation Of Fat Cell Differentiation Cellular Response To Glucocorticoid Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Corticosteroid Regulation Of RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Corticosteroid Stimulus Anatomical Structure Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Focal Adhesion Assembly Regulation Of RNA Biosynthetic Process Response To Growth Factor Response To Transforming Growth Factor Beta Negative Regulation Of Nucleobase-containing Compound Metabolic Process ERBB Signaling Pathway Regulation Of Cell-substrate Junction Organization MAP Kinase Activity Regulation Of Primary Metabolic Process Regulation Of Cytoskeleton Organization Cellular Response To Steroid Hormone Stimulus Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Projection Extension Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Migration Positive Regulation Of Catabolic Process Response To Wounding
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